176870

Angiotensinogen, Human Plasma

Native angiotensinogen from human plasma that is cleaved by renin to generate angiotensin I. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance.

• Synonyme(s) : Angiotensinogen, Human Plasma, AGT, Hypertensinogen, Serpin A8
• Numéro CAS: 11002-13-4
• Numéro MDL: MFCD00151759
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (SDS-PAGE)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Technique(s): cell based assay: suitable
• Solubilité: water: soluble
• Numéro d'accès NCBI: NM_001384479
• Numéro d'accès UniProt: P01019
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Informations sur le gène: human ... AGT(183)

Description

Description générale

Research area: CELL SIGNALING

Native angiotensinogen from human plasma is an α2-globulin present in plasma at about 7 mg/100 ml.

Angiotensinogen serves as a precursor for the production of angiotensin. In humans, angiotensinogen is composed of 485 amino acids. It is primarily synthesized and continuously secreted by the liver.

Application

Angiotensinogen has been used for the detection and analysis of the complexes formed between angiotensinogen and proform of eosinophil major basic protein (ProMBP) in both serum and amniotic fluid during pregnancy through ELISA.

Actions biochimiques/physiologiques

Angiotensinogen acts as a precursor molecule in the renin-angiotensin-aldosterone system (RAAS) pathway. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance. Moreover, overactivation of the RAAS system has been associated with the development of several types of cancer, cardiovascular and renal diseases. Furthermore, in certain cancers angiotensin II has been shown to promote cancer metastasis.

Avertissement

Toxicity: Standard Handling (A)

Forme physique

Lyophilized from 50 mM sodium phosphate, 150 mM NaCl, pH 7.0.

Notes préparatoires

Please refer to vial label for lot-specific concentration prior to lyophilization.

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Jeunemaitre, X., et al. 1992. Cell71, 169.
Tewksbury, D.A. 1983. Fed. Proc.42, 2724.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3