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Key Documents

810603C

Avanti

16:0-10 Doxyl PC

Avanti Research™ - A Croda Brand 810603C

Synonyme(s) :

1-palmitoyl-2-stearoyl-(10-doxyl)-sn-glycero-3-phosphocholine

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About This Item

Formule empirique (notation de Hill):
C46H90N2O10P
Numéro CAS:
188004-25-3
Poids moléculaire :
862.19
Code UNSPSC :
41141825
Nomenclature NACRES :
NA.12

Pureté

>99% (TLC)

Forme

liquid

Conditionnement

pkg of 1 × 1 mL (810603C-1mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 810603C

Concentration

1 mg/mL (810603C-1mg)

Type de lipide

ESR probes
phospholipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Catégories apparentées

Description générale

Avanti′s nitroxide spin product listing is a group of compounds designed to act as membrane probes. A variety of positions down the hydrophobic chain are labeled with the nitroxide functional groups to allow probing the membrane at various depths. These compounds have been synthesized from 1-palmitoyl-2-hydroxy-sn-glycerol-3-phosphocholine with the product being purified by column chromatography. Various n-doxyl phosphocholines have been recently used as biophysical tools to elucidate membrane trafficking with phosphatidylinositol transfer proteins and as fluorescent quenchers in lipid bilayer structural studies.
Phosphocholine is considered as a precursor molecule. It is formed during the breakdown of phosphatidylcholine metabolism.

Application

16:0-10 Doxyl PC may be used in vesicles for quenching PT-(1–46)F4W fluorescence. It may also be used in vesicles to check the fluorescence emission spectra in order to measure the penetration depth of the peptides′ tryptophan residues in lipid bilayer.

Actions biochimiques/physiologiques

Phosphatidylcholine (PC) lowers the levels of cholesterol and triglycerides.

Conditionnement

5 mL Clear Glass Sealed Ampule (810603C-1mg)

Notes préparatoires

Product use: To prevent aggregation, prepare water-based solutions of 2 mM stock solutions of n-DOXYL PCs and store in plastic. Dilute stock solutions to 0.03- 0.1 mM solutions for EPR studies. For liposome preparations in fluorescent quenching measurements, dissolve the doxyl lipid in 150 μl absolute ethanol for a concentration of 40.3 mM , Additional supplemental information.

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Organes cibles

Central nervous system, Liver,Kidney

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Biology-cancer metabolic phenotype
NMR Metabolomics in Cancer Research, 15-138 (2013)
Q Wang et al.
Biochimica et biophysica acta, 1324(1), 69-75 (1997-02-21)
The N-terminal signal sequence of glucitol permease of Escherichia coli (Gut22: MIETITPGAVWFIGLFQKGGEC) and its analog (Gut22Ana: MIETITHGAEWFIGLFQKGGEC) were synthesized. The analog had a Pro residue substituted for the His at the 7th position of Gut22 and a Val residue substituted
L A Falls et al.
The Journal of biological chemistry, 276(26), 23895-23902 (2001-04-20)
The hydrophobic omega-loop within the prothrombin gamma-carboxyglutamic acid-rich (Gla) domain is important in membrane binding. The role of this region in membrane binding was investigated using a synthetic peptide, PT-(1-46)F4W, which includes the N-terminal 46 residues of human prothrombin with
Insight into antibody combining sites using nuclear magnetic resonance and spin label haptens
McConnell HM
Advances in Protein Chemistry, 49, 135-148 (1996)
ESR of spin-labeled bacteriophage M13 coat protein in mixed phospholipid bilayers
de Jongh HH
Biochimica et Biophysica Acta, 1024, 82-88 (1990)
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