QBD11135

Phthalimidooxy-dPEG^®₁₂-NHS ester

• Formule empirique (notation de Hill): C₃₉H₆₀N₂O₁₉
• Poids moléculaire : 860.90
• Numéro MDL: MFCD21363338
• Code UNSPSC : 12352108
• ID de substance PubChem : 329823971
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: >90%
• Forme: solid or viscous liquid
• Pertinence de la réaction: reactivity: thiol reactive; reagent type: cross-linking reagent; reactivity: amine reactive
• Architecture des polymères: shape: linear; functionality: heterobifunctional
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCON1C(C2=C(C1=O)C=CC=C2)=O)ON3C(CCC3=O)=O

Description

Caractéristiques et avantages

Phthalimidooxy-dPEG^®₁₂-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG^® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG^® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.

Informations légales

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable