930075
2-fluoro-6-(pyrimidin-5-yl)aniline
≥95%
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About This Item
Formule empirique (notation de Hill):
C10H8FN3
Numéro CAS:
Poids moléculaire :
189.19
Code UNSPSC :
12352106
Nomenclature NACRES :
NA.06
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Niveau de qualité
Pureté
≥95%
Forme
powder, crystals or chunks
Couleur
light yellow
Température de stockage
−20°C
Chaîne SMILES
NC1=C(C2=CN=CN=C2)C=CC=C1F
Application
2-fluoro-6-(pyrimidin-5-yl)aniline is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.
2-fluoro-6-(pyrimidin-5-yl)aniline is an effective TDG for meta directed C-H functionalization of aldehyde substituted target compounds, with high selectivity.
2-fluoro-6-(pyrimidin-5-yl)aniline is an effective TDG for meta directed C-H functionalization of aldehyde substituted target compounds, with high selectivity.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Sukdev Bag et al.
Nature communications, 12(1), 1393-1393 (2021-03-04)
Despite the widespread applications of C-H functionalization, controlling site selectivity remains a significant challenge. Covalently attached directing groups (DGs) served as ancillary ligands to ensure ortho-, meta- and para-C-H functionalization over the last two decades. These covalently linked DGs necessitate
Zhen Li et al.
Science (New York, N.Y.), 372(6549), 1452-1457 (2021-11-30)
Hydroxylation of aryl carbon-hydrogen bonds with transition metal catalysts has proven challenging when oxygen is used as the oxidant. Here, we report a palladium complex bearing a bidentate pyridine/pyridone ligand that efficiently catalyzes this reaction at ring positions adjacent to
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