569253-U
Discovery® HS C18 (3 µm) HPLC Columns
L × I.D. 5 cm × 2.1 mm, HPLC Column
Synonyme(s) :
Discovery RP18 HPLC Column
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About This Item
Code UNSPSC :
41115700
eCl@ss :
32110501
Nomenclature NACRES :
SB.52
Produits recommandés
product name
Colonne HPLC Discovery® HS C18, 3 μm particle size, L × I.D. 5 cm × 2.1 mm
Matériaux
stainless steel column
Agence
suitable for USP L1
Gamme de produits
Discovery®
Caractéristiques
endcapped
Fabricant/nom de marque
Discovery®
Conditionnement
1 ea of
Ampleur du marquage
20% Carbon loading
Paramètres
≤70 °C temp. range
400 bar pressure (5801 psi)
Technique(s)
HPLC: suitable
LC/MS: suitable
L × D.I.
5 cm × 2.1 mm
Superficie
300 m2/g
Couverture de surface
3.2 μmol/m2
Impuretés
<10 ppm metals
Matrice
silica gel, high purity, spherical particle platform
fully porous particle
Groupe de la matrice active
C18 (octadecyl) phase
Taille des particules
3 μm
Dimension de pores
120 Å
operating pH range
2-8
Application(s)
food and beverages
Technique de séparation
reversed phase
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Description générale
Discovery® HS C18 HPLC column (L × I.D. 5 cm × 2.1 mm) is commonly found to be stable under acidic and basic conditions.
Application
- Stereoselective separation of omeprazole and 5-hydroxy-omeprazole using dried plasma spots and a heart-cutting 2D-LC approach for accurate CYP2C19 phenotyping: This research utilizes the Discovery® HS C18 HPLC column for its superior selectivity and sensitivity in pharmacogenetic studies, providing vital data for personalized medicine approaches in drug metabolism (Abouir et al., 2024).
- A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies: This study highlights the effectiveness of the Discovery® HS C18 column in the rapid and accurate analysis of molnupiravir, emphasizing its role in supporting fast-paced pharmaceutical research and development (Reçber et al., 2022).
- Sensitive Analysis of Idarubicin in Human Urine and Plasma by Liquid Chromatography with Fluorescence Detection: This application underlines the Discovery® HS C18 column′s high sensitivity and robustness in clinical diagnostics, crucial for monitoring therapeutic drugs and their metabolites in complex biological matrices (Maliszewska et al., 2020).
Caractéristiques et avantages
- Stables, faible relargage pour applications LC-MS
- Changement d′échelle de l′analytique à la préparative
- Haute stabilité pour assurer une excellente reproductibilité d′injection à injection et de lot à lot
- Hydrophobicité plus élevée pour une meilleure résolution des analytes difficiles
Informations légales
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
Application
Colonne de garde
Réf. du produit
Description
Tarif
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Fazli Khuda et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 944, 114-122 (2013-12-10)
A simple, specific, precise and rapid RP-HPLC-UV method was developed for simultaneous determination of lumefantrine and its metabolite desbutyl lumefantrine in human plasma. Experimental parameters were optimized and the method was validated according to standard guidelines. The method showed adequate
Abad Khan et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(28), 2782-2788 (2010-09-11)
A rapid, inexpensive, sensitive and specific HPLC-ECD method for the determination of lipoic acid in human plasma was developed and validated over the linearity range of 0.001-10μg/ml using naproxen sodium as an internal standard (IS). Extraction of lipoic acid and
Swati Jaiswal et al.
Journal of chromatographic science, 55(6), 617-624 (2017-03-24)
Tuberculosis (TB) with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome represents the most common infectious diseases worldwide. Anti-TB drugs are used concurrently with antiretroviral drug for treatment of TB-HIV co-morbidities. Due to lower risk of interaction with protease inhibitors, rifabutin is
Jolanta Flieger et al.
Journal of separation science, 34(7), 733-739 (2011-03-02)
Highly hydrophilic compounds belonging to biogenic amines were analysed in the reversed-phase system, modified with the addition of ionic liquids: 1-ethyl-3-methyl-imidazolium hexafluorophosphate (EMIM PF(6)) and chaotropic salt NaPF(6) on Discovery HS C18 column at acidic conditions. The effect of the
Bhavin N Patel et al.
Biomedical chromatography : BMC, 22(11), 1213-1224 (2008-07-25)
A simple, precise and accurate assay for the determination of 6-methoxy-2-naphthylacetic acid (6-MNA), an active metabolite of nabumetone in human plasma, was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The analyte (6-MNA) and propranolol (internal standard, IS) were
Contenu apparenté
HPLC DiscoveryBIO HS C18 products. Available in 3µm, 5µm and 10µm particle sizes.
Chromatograms
application for HPLCapplication for HPLCNotre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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