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V4640

Sigma-Aldrich

VU0357017 monohydrochloride

≥98% (HPLC)

Synonyme(s) :

4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride, CID 25010775, ML071 hydrochloride, SID 56353039

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About This Item

Formule empirique (notation de Hill) :
C18H27N3O3 · HCl
Numéro CAS:
1135242-13-5
Poids moléculaire :
369.89
Numéro MDL:
MFCD17215959
Code UNSPSC :
12352200
ID de substance PubChem :
329829053
Nomenclature NACRES :
NA.77

176,00 $

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Essai

≥98% (HPLC)

Forme

powder

Couleur

white to off-white

Solubilité

DMSO: ≥10 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

Cl.CCOC(=O)N1CCC(CC1)NCCNC(=O)c2ccccc2C

InChI

1S/C18H27N3O3.ClH/c1-3-24-18(23)21-12-8-15(9-13-21)19-10-11-20-17(22)16-7-5-4-6-14(16)2;/h4-7,15,19H,3,8-13H2,1-2H3,(H,20,22);1H

Clé InChI

XKJQVUIXSBOCPP-UHFFFAOYSA-N

Actions biochimiques/physiologiques

VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist.
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.

Caractéristiques et avantages

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
050M4620V
050M4620

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Consulter la Bibliothèque de documents

Donghyun Jee et al.
Investigative ophthalmology & visual science, 54(10), 6827-6833 (2013-09-26)
We evaluated the prevalence and risk factors for diabetic retinopathy (DR) in a representative Korean population. This cross-sectional study involved 16,109 subjects aged >40 years who had participated in the Korean National Health and Nutrition Survey from 2008 to 2011.
Andrew P Bacon et al.
PloS one, 8(9), e73182-e73182 (2013-09-26)
Endurance exercise training studies frequently show modest changes in VO2max with training and very limited responses in some subjects. By contrast, studies using interval training (IT) or combined IT and continuous training (CT) have reported mean increases in VO2max of
Suzette Glasner-Edwards et al.
Journal of dual diagnosis, 9(2), 123-128 (2013-09-26)
Although trauma is a well-established risk factor for substance use disorders, little is known about the association between posttraumatic stress disorder (PTSD) and treatment outcomes among methamphetamine users. In the present study, we examine the relationship between PTSD and post-treatment
Najmeh Haseli et al.
Hepatitis monthly, 13(7), e10257-e10257 (2013-09-26)
Liver transplantation is considered as the standard treatment for both children and adults with end-stage liver diseases. Using this method, children who have no chance for life can live a much longer life .Shiraz Transplant Center is the major pediatric
Zhang Qiao et al.
International journal of endocrinology, 2013, 150461-150461 (2013-09-26)
Objective. To evaluate vitamin D status and serum parathyroid hormone (IPTH) of healthy adults living in Guiyang. Design and Participants. We conducted a cross-sectional evaluation in the General Community in Guiyang by cluster sampling method. The data was a part
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Articles

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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