T4425

(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride

≥98% (HPLC), powder

• Synonyme(s) : (6R)-BH₄
• Formule empirique (notation de Hill): C₉H₁₅N₅O₃ · 2HCl
• Numéro CAS: 69056-38-8
• Poids moléculaire : 314.17
• Numéro MDL: MFCD00891665
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277922
• Nomenclature NACRES : NA.77

Propriétés

• product name: (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride,
• Niveau de qualité: 200
• Solubilité: water, oxygen free: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Température de stockage: −20°C
• Chaîne SMILES: Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2=C(N1)C(=O)NC(N)=N2
• InChI: 1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
• Clé InChI: RKSUYBCOVNCALL-NTVURLEBSA-N
• Informations sur le gène: human ... PAH(5053)

Description

Description générale

Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase.

Application

(6R)-BH₄ has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues. (6R)-BH₄ has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay.

Actions biochimiques/physiologiques

Lack of tetrahydrobiopterin may cause hyperphenylalaninemia. Diseases like, Parkinson′s, autism, depression and Alzheimer′s shows low concentration of tetrahydrobiopterin in the cerebrospinal fluid. This coenzyme participates in dopamine (DA) synthesis.

Caractéristiques et avantages

This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis and Nitric Oxide Synthases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride ((6R)-BH₄ ) is soluble in oxygen free water at 19.60 - 20.40 mg/ml and yields a clear to slightly hazy, colorless to faint yellow solution.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable