SRP8049
Periostin mouse
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
Synonyme(s) :
OSF-2, Osteoblast-specific factor 2, PC cell-derived growth factor
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10 μG
384,00 $
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10 μG
384,00 $
About This Item
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32
384,00 $
Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit.
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Source biologique
mouse
Produit recombinant
expressed in CHO cells
Étiquette/Marqueur
FLAG® tagged
Essai
>95% (SDS-PAGE)
Forme
lyophilized
Poids mol.
~85 kDa
Conditionnement
pkg of 10 μg
Conditions de stockage
avoid repeated freeze/thaw cycles
Impuretés
<0.1 EU/μg endotoxin, tested
Couleur
white
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
mouse ... Postn(50706)
Description générale
Periostin (POSTN) is also called as osteoblast-specific factor 2.[1] It is a matricellular protein,[1] located in the alveolar walls.[1] This gene is located on human chromosome 13q13.[2]
Periostin was originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein (BMP-2). Abnormal expression of periostin is also linked to angiogenesis and metastasis in epithelial tumors.
Actions biochimiques/physiologiques
Periostin (POSTN) participates in collagen fibrillogenesis.[1] It plays a major role in the development of scar after traumatic spinal cord injury (SCI).[3] Periostin controls the activities of fibrocyte to stimulate myofibroblast differentiation and lung fibrosis.[1] It modulates the amount of collagen in tissue. Periostin also participates in the assembly of the extracellular matrix (ECM) architecture.[4]
Forme physique
Lyophilized from PBS.
Reconstitution
Reconstitute with 100 μL deionized water.
Autres remarques
Mouse periostin (aa 24-783) (isoform 5) is fused at the C-terminus to a FLAG®-tag.
Informations légales
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Nicolette M Jeanblanc et al.
Clinica chimica acta; international journal of clinical chemistry, 464, 228-235 (2016-10-19)
Periostin is being investigated as a potential biomarker for T-helper-2 (Th2)-driven asthma or eosinophilic inflammation and may help to identify patients more likely to benefit from interleukin-13-targeted treatments. We report the development and analytic performance of the investigational use only
Shoichiro Ohta et al.
PloS one, 12(3), e0174547-e0174547 (2017-03-30)
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was
Periostin promotes scar formation through the interaction between pericytes and infiltrating monocytes/macrophages after spinal cord injury.
Yokota K, et al.
The American Journal of Pathology, 187(3), 639-653 (2017)
Teresa Cobo et al.
PloS one, 11(1), e0147837-e0147837 (2016-01-26)
Periostin is an extracellular matrix protein highly expressed in collagen-rich tissues subjected to continuous mechanical stress. Functionally, periostin is involved in tissue remodeling and its altered function is associated to numerous pathological processes. In orthodontics, periostin plays key roles in
Jin Ho Hwang et al.
American journal of nephrology, 46(6), 501-517 (2017-12-22)
Periostin is responsible for tissue regeneration, fibrosis, and wound healing via its interaction with integrin. Recently, the role of periostin has been shown to contribute to fibrosis in chronic kidney disease. We investigated the role of periostin and the effect
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