SRP3331
G-CSF from mouse
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonyme(s) :
CSF-3, MGI-1G, pluripoietin
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About This Item
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
mouse
Produit recombinant
expressed in E. coli
Pureté
≥98% (HPLC)
≥98% (SDS-PAGE)
Forme
lyophilized
Puissance
≤0.05 ng/mL
Poids mol.
19.0 kDa
Conditionnement
pkg of 10 μg
Impuretés
endotoxin, tested
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
mouse ... CSF3(12985)
Description générale
Colony stimulating factor 3 (CSF-3) or granulocyte colony stimulating factor (G-CSF) is a hematopoietic growth factor. It is produced in response to specific stimulation by a variety of cells including macrophages, fibroblasts, endothelial cells and bone marrow stroma. Human and murine G-CSF is cross-species reactive. Recombinant murine G-CSF is a 19.0kDa protein consisting of 179 amino acid residues.
Actions biochimiques/physiologiques
Colony stimulating factor 3 (CSF-3) or granulocyte colony stimulating factor (G-CSF) stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It also has a role in macrophage generation and may be involved in immune modulation. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation.
Forme physique
Lyophilized from 10 mM Sodium Citrate, pH 4.0.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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The importance of the granulocyte-colony stimulating factor in oncology.
Cetean S
Clujul Medical (1957), 88(4), 468-472 (2015)
H S Lu et al.
Archives of biochemistry and biophysics, 268(1), 81-92 (1989-01-01)
Molecular characteristics and secondary structures of recombinant methionyl human granulocyte colony stimulating factor produced by genetically engineered Escherichia coli are described. Limited radiolabeling of the protein with tritiated iodoacetate and determination of the labeled residue revealed that this recombinant protein
Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages.
Meshkibaf S
Cytokine, 78, 69-78 (2016)
Gerald Wirnsberger et al.
Nature genetics, 46(9), 1028-1033 (2014-08-19)
Neutrophils are key innate immune effector cells that are essential to fighting bacterial and fungal pathogens. Here we report that mice carrying a hematopoietic lineage-specific deletion of Jagn1 (encoding Jagunal homolog 1) cannot mount an efficient neutrophil-dependent immune response to
Yaron Vagima et al.
PLoS pathogens, 11(5), e1004893-e1004893 (2015-05-15)
Pneumonic plague is a fatal disease caused by Yersinia pestis that is associated with a delayed immune response in the lungs. Because neutrophils are the first immune cells recruited to sites of infection, we investigated the mechanisms responsible for their
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