SML2756

Bremelanotide acetate

≥98% (HPLC)

• Synonyme(s) : Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys (Asp-Lys), acetate salt, Acetyl-[Nle4, Asp5, D-Phe7, Lys10]-cyclo-α-melanocyte, PT 141 acetate, PT-141 acetate, PT141 acetate
• Formule empirique (notation de Hill): C₅₀H₆₈N₁₄O₁₀ · xC₂H₄O₂
• Numéro CAS: 1607799-13-2
• Poids moléculaire : 1025.16 (free base basis)
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: [nH]1cncc1C[C@@H]2NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC2=O)Cc5ccccc5)CCCN=C(N)N)Cc3c4c([nH]c3)cccc4)C(=O)O)NC(=O)[C@@H](NC(=O)C)CCCC.OC(=O)C
• InChI: 1S/C50H68N14O10.C2H4O2/c1-3-4-16-35(58-29(2)65)43(67)64-41-25-42(66)54-20-11-10-18-37(49(73)74)60-46(70)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(68)36(19-12-21-55-50(51)52)59-45(69)38(22-30-13-6-5-7-14-30)61-47(71)40(63-48(41)72)24-32-27-53-28-57-32;1-2
• Clé InChI: MAYUSRUHXFWITM-GBRHMYBBSA-N

Description

Actions biochimiques/physiologiques

Brain-penetrant alpha-melanocyte-stimulating hormone (α-MSH)-derived melanocortin receptors (MC1R, MC3R, MC4R) agonist with in vivo sexual arousal efficacy.

Bremelanotide (PT-141) is a brain-penetrant, alpha-melanocyte-stimulating hormone (α-MSH)-derived cyclic heptapeptide agonist toward melanocortin receptors, including MC1R, MC3R and MC4R (affinty = 10 nM by competitive binding against 0.2 nM NDP-α-MSH using human MC4R-expressing HEK-293). Bremelanotide induces cAMP accumulation in hMC4R-expressing HEK-293 cells and exhibits in vivo sexual arousal efficacy among both male (50 μg/kg intranasally or 50-500 pg/kg via lateral ventricle injection) and female rats (100-200 μg/kg sc or 800 μg/kg via lateral ventricle injection) by activating neurons in brain regions responsible for sexual function.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable