SAE0216
Pepstatin, water soluble
semisynthetic, >=95% pure
Synonyme(s) :
GKK pepstatyl, Gly-Lys-Lys-pepstatyl, Pepsin inhibitor
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Code UNSPSC :
12352202
Produits recommandés
Source biologique
synthetic
Niveau de qualité
Forme
powder
Conditions d'expédition
wet ice
Température de stockage
-10 to -25°C
Description générale
Pepstatin water soluble is a semisynthetic product derived from microbial Pepstatin A by the addition of the tri-peptide Gly-Lys-Lys-OH. Pepstatin water soluble is a novel product that has the same protease inhibition activity as Pepstatin A, but with increased solubility in water and in physiological media. The increased water solubility provides new options for using this inhibitor in aqueous solutions. Pepstatin water soluble was first described by Austen at al,. The published Ki for inhibition of Pepsin activity is the same as Pepstatin A. While Pepstatin A is only sparingly soluble in water or PBS, the water soluble Pepstatin product is soluble in water and PBS at concentration of 60 mg/ml .
Application
Both Pepstatin A and Water soluble Pepstatin are potent inhibitors of aspartyl proteases. Both of them contain the unusual amino acid statine. Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, , cathepsin D , bovine chymosin, and protease B (Aspergillus Niger).4 Solubilized γ-secretase6 and retroviral protease7 are also inhibited by Pepstatin A.
Caractéristiques et avantages
- Same protease inhibition activity as Pepstatin A
- Icreased solubility in water and in physiological media
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
J Marciniszyn et al.
Advances in experimental medicine and biology, 95, 199-210 (1977-01-01)
Pepstatin is a low molecular weight, potent inhibitor specific for acid proteases with a Ki value of about 10(-10)M for pepsin. The chemical structure of pepstatin is essentially a hexapeptide which contains two residues of an unusual amino acid, 4-amino-3-hydroxy-6-methylheptanoic
Solid-phase synthesis of a soluble pepstatin derivative suitable for therapeutic use.
B M Austen et al.
Bioscience reports, 2(6), 427-432 (1982-06-01)
K Takahashi et al.
Journal of biochemistry, 80(3), 497-506 (1976-09-01)
Comparative studies have been made on the effects of diazoacetyl-DL-norleucine methyl ester (DAN), 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP) and pepstatin on acid proteases, including those from Acrocylindrium sp., Aspergillus niger, Aspergillus saitoi, Mucor pusillus, Paecilomyces varioti, Rhizopus chinensis, and Trametes sanguinea, and also
Structures and activities of protease inhibitors of microbial origin.
H Umezawa
Methods in enzymology, 45, 678-695 (1976-01-01)
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique