SAB4502419
Anti-Peripherin antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
PERI, PRPH
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Conjugué
unconjugated
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
antigen 53 kDa
Espèces réactives
rat, human
Concentration
~1 mg/mL
Technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... PRPH(5630)
Description générale
Anti-Peripherin antibody detects endogenous levels of total Peripherin protein.
The PRPH (peripherin) gene is mapped to human chromosome 12q13.12. This gene codes for a 57 kDa intermediate filament protein. Peripherin is predominantly expressed in the peripheral neurons.
Immunogène
The antiserum was produced against synthesized peptide derived from human Peripherin.
Immunogen Range: 421-470
Immunogen Range: 421-470
Actions biochimiques/physiologiques
Peripherin is known to be associated with the mechanism of organelle transport, function and positioning. It also forms an important part of the cytoskeleton. Mutation in PRPH (peripherin) is observed in amyotrophic lateral sclerosis. Peripherin participates in the elongation of motor axons. Upregulation of PRPH is noticed in neuronal injury.
Caractéristiques et avantages
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Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
nwg
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Joshua J Emrick et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(51), E12091-E12100 (2018-11-23)
Atopic dermatitis (AD) is the most common skin disease in children. It is characterized by relapsing inflammation, skin-barrier defects, and intractable itch. However, the pathophysiology of itch in AD remains enigmatic. Here, we examine the contribution of Tmem79, an orphan
Paulo Victor Sgobbi de Souza et al.
Arquivos de neuro-psiquiatria, 73(12), 1026-1037 (2015-10-16)
Amyotrophic lateral sclerosis represents the most common neurodegenerative disease leading to upper and lower motor neuron compromise. Although the vast majority of cases are sporadic, substantial gain has been observed in the knowledge of the genetic forms of the disease
Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin.
Cogli L
Acta Neuropathologica, 125(2), 257-272 (2013)
Jesse McLean et al.
Journal of neurochemistry, 114(4), 1177-1192 (2010-06-11)
Peripherin is a type III intermediate filament protein that is up-regulated during neuronal injury and is a major component of pathological inclusions found within degenerating motor neurons of patients with amyotrophic lateral sclerosis (ALS). The relationship between these inclusions and
Stephanie Shiers et al.
Pain, 161(11), 2494-2501 (2020-08-23)
SARS-CoV-2 has created a global crisis. COVID-19, the disease caused by the virus, is characterized by pneumonia, respiratory distress, and hypercoagulation and can be fatal. An early sign of infection is loss of smell, taste, and chemesthesis-loss of chemical sensation.
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