PZ0129

CP-380736

≥98% (HPLC)

• Synonyme(s) : 6,7-Bis(2-methoxyethoxy)-3,4-dihydroquinazolin-4-one, 6,7-Bis(2-methoxyethoxy)-4(3H)-quinazolinone, PF-00520893
• Formule empirique (notation de Hill): C₁₄H₁₈N₂O₅
• Numéro CAS: 179688-29-0
• Poids moléculaire : 294.30
• Numéro MDL: MFCD02678087
• Code UNSPSC : 51111800
• ID de substance PubChem : 329823716
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white to light tan
• Solubilité: DMSO: ≥10 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: COCCOc1cc2N=CNC(=O)c2cc1OCCOC
• InChI: 1S/C14H18N2O5/c1-18-3-5-20-12-7-10-11(15-9-16-14(10)17)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3,(H,15,16,17)
• Clé InChI: PMQWTUWLIGJTQD-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

CP-380736 is an inhibitor of the epidermal growth factor receptor (EGFR). EGFR is a tyrosine kinase that activates MAPK, JNK, and Akt pathways, and is an important mediator of several types of cancer, including lung cancer and glioblastoma multiforme.

CP-380736 is selective inhibitor of epidermal growth factor receptor.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable