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P4510

Sigma-Aldrich

Poly-ε-Cbz-L-lysine

mol wt 500-4,000

Synonyme(s) :

N6-[(phenylmethoxy)carbonyl]-L-lysine homopolymer

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About This Item

Numéro CAS:
25931-47-9
Numéro MDL:
MFCD00166378
Code UNSPSC :
12352209
Nomenclature NACRES :
NA.26

Forme

powder

Poids mol.

500-4,000

Couleur

white

Température de stockage

−20°C

InChI

1S/C14H20N2O4/c15-12(13(17)18)8-4-5-9-16-14(19)20-10-11-6-2-1-3-7-11/h1-3,6-7,12H,4-5,8-10,15H2,(H,16,19)(H,17,18)/t12-/m0/s1

Clé InChI

CKGCFBNYQJDIGS-LBPRGKRZSA-N

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Application


  • Transfection by polyethyleneimine-coated microspheres.: This study explores the use of Poly-e-Cbz-L-lysine in coating microspheres with polyethyleneimine for enhanced cell transfection, demonstrating improved efficiency and potential applications in gene therapy (Manuel WS et al., 2001).

  • Transfection of cells mediated by biodegradable polymer materials with surface-bound polyethyleneimine.: The research focuses on biodegradable polymer materials, including Poly-e-Cbz-L-lysine, for cell transfection, highlighting their biodegradability and effectiveness in delivering genetic material (Zheng J et al., 2000).

  • Production of microspheres with surface amino groups from blends of Poly(Lactide-co-glycolide) and Poly(epsilon-CBZ-L-lysine) and use for encapsulation.: This paper discusses the creation of microspheres with surface amino groups using blends of Poly-e-Cbz-L-lysine, which are then used for encapsulating active agents, indicating applications in drug delivery systems (Zheng J et al., 1999).

  • Modification of materials formed from poly(L-lactic acid) to enable covalent binding of biopolymers: application to high-density three-dimensional cell culture in foams with attached collagen.: The study examines the modification of poly(L-lactic acid) materials with Poly-e-Cbz-L-lysine to covalently bind biopolymers, facilitating high-density 3D cell culture applications (Zheng J et al., 1998).

Remarque sur l'analyse

Molecular weight by Electrospray Mass-Spectrometry

Autres remarques

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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W S Manuel et al.
Journal of drug targeting, 9(1), 15-22 (2001-05-30)
Polyethyleneimine (PEI) can be used as a DNA delivery mechanism in cell culture and in vivo. Cells can be transfected by using surface-bound PEI, as well as by PEI/DNA microparticles. In the present experiments we extended these observations by preparing
Chimdiya Onwukwe et al.
Bioconjugate chemistry, 29(7), 2436-2447 (2018-07-03)
Bleeding from traumatic injury is the leading cause of death for young people across the world, but interventions are lacking. While many agents have shown promise in small animal models, translating the work to large animal models has been exceptionally
J Zheng et al.
Biotechnology progress, 16(2), 254-257 (2000-04-08)
Poly(epsilon-CBZ-L-lysine) can be mixed with biodegradable polymers such as poly(D,L-lactic-co-glycolic acid) or poly(L-lactic acid) and formed into films, foams, or microspheres. Surface amino groups may then be deprotected with acid or lithium/liquid ammonia. The amino groups serve as a method
Qian Guo et al.
Journal of controlled release : official journal of the Controlled Release Society, 303, 117-129 (2019-04-27)
Brain metastases present mostly multifocal, infiltrative and co-opting growth with the blood-brain barrier (BBB) remaining intact. The BBB, as the barrier of drug delivery to such lesions, is the major cause of the failure of systemic drug therapy and needs
J Zheng et al.
Biotechnology progress, 15(4), 763-767 (1999-08-12)
Microspheres were formed from blends of the biodegradable polymer poly(DL-lactic-co-glycolic acid) (PLGA) together with poly(epsilon-CBZ-L-lysine) (PCBZL) by a double-emulsification/solvent evaporation technique. The size of the microspheres formed by this method was dependent both on the total concentration of the polymers

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