M9292

Memantine hydrochloride

≥98% (GC), powder, NMDA glutamate receptor antagonist

• Synonyme(s) : 3,5-Dimethyl-1-adamantanamine hydrochloride, 3,5-Dimethylamantadine hydrochloride, 3,5-Dimethyltricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride
• Formule empirique (notation de Hill): C₁₂H₂₁N · HCl
• Numéro CAS: 41100-52-1
• Poids moléculaire : 215.76
• Numéro CE : 255-219-6
• Numéro MDL: MFCD00214336
• Code UNSPSC : 12352200
• ID de substance PubChem : 24277990
• Nomenclature NACRES : NA.77

Propriétés

• Nom du produit: Memantine hydrochloride, ≥98% (GC)
• Niveau de qualité: 100
• Essai: ≥98% (GC)
• Forme: powder
• Auteur: Forest Labs
• Chaîne SMILES: Cl.C[C@]12CC3C[C@](C)(C1)CC(N)(C3)C2
• InChI: 1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;
• Clé InChI: LDDHMLJTFXJGPI-VXMZOEJHSA-N
• Informations sur le gène: human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

Description

Application

Memantine hydrochloride has been used:

• as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity[1]
• to intraperitoneally inject experimental animal to study its effect on traumatic injury[2]
• as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration[3]

Actions biochimiques/physiologiques

Low-affinity NMDA glutamate receptor antagonist; stimulates dopamine release.

Memantine is effective against Alzheimer′s disease and Parkinson′s disease. It is also useful in treating epilepsy, motor neurone disease and trauma.[4]

Caractéristiques et avantages

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)