I0274
myo-Inositol Monophosphatase from bovine brain
lyophilized powder, 5-20 units/mg protein
Synonyme(s) :
myo-Inositol monophosphate phosphohydrolase
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About This Item
Numéro CAS:
Numéro MDL:
Code UNSPSC :
12352204
Produits recommandés
Forme
lyophilized powder
Activité spécifique
5-20 units/mg protein
Composition
Protein, ~0.5% Bradford
Température de stockage
−20°C
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Application
The enzyme plays a critical role in the recycling of inositol to phosphoinositides in the mammalian brain and participates in the phosphatidylinositol signaling pathway. It is inhibited non-competitively by Li+, which may be significant in the treatment of manic depression. The enzyme may help in identifying less toxic substitutes for lithium in manic depressive therapy.
Définition de l'unité
One unit will form 1.0 μmole of phosphate from inositol 1-phosphate per min at pH 7.4 at 37°C.
Forme physique
Lyophilized powder containing HEPES buffer salts, pH 7.5, and stabilizer
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Équipement de protection individuelle
Eyeshields, Gloves, type N95 (US)
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S J Pollack et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(13), 5766-5770 (1994-06-21)
myo-Inositol monophosphatase (myo-inositol-1-phosphate phosphohydrolase, EC 3.1.3.25) is an attractive target for mechanistic investigation due to its critical role in the phosphatidylinositol signaling pathway and the possible relevance of its inhibition by Li+ to manic depression therapy. The x-ray crystallographic structure
Christopher A Broberg et al.
Science (New York, N.Y.), 329(5999), 1660-1662 (2010-08-21)
The marine bacterium Vibrio parahaemolyticus causes gastroenteritis in humans and encodes the type III effector protein VPA0450, which contributes to host cell death caused by autophagy, cell rounding, and cell lysis. We found that VPA0450 is an inositol polyphosphate 5-phosphatase
Svetlana Kalujnaia et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(10), 3981-3991 (2010-06-16)
This study investigated the expression and tissue distribution of inositol monophosphatase (IMPA1) and characterized its role in salinity adaptation in the eel. The coding sequence of eel IMPA1 was determined and confirmed to be orthologous to the mammalian gene/enzyme by
Sudipta Bhattacharyya et al.
Biochimie, 94(3), 879-890 (2011-12-27)
Inositol monophosphatase (IMPase) family of proteins are Mg(2+) activated Li(+) inhibited class of ubiquitous enzymes with promiscuous substrate specificity. Herein, the molecular basis of IMPase substrate specificity is delineated by comparative crystal structural analysis of a Staphylococcal dual specific IMPase/NADP(H)
Livia Pasquali et al.
Behavioural pharmacology, 21(5-6), 473-492 (2010-08-12)
This is a short overview focusing on the biochemical interactions underlying the protective effects of lithium at the neuronal level. These include lithium modulation of autophagy, growth factors, excitotoxicity, and a variety of mechanisms underlying cell death, neurogenesis, and neuronal
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