C3144

Coenzyme A sodium salt hydrate

cofactor for acyl transfer

• Synonyme(s) : CoA Na₂
• Formule empirique (notation de Hill) : C₂₁H₃₆N₇O₁₆P₃S · xNa⁺ · yH₂O
• Numéro CAS: 55672-92-9
• Poids moléculaire : 767.53 (anhydrous free acid basis)
• Numéro CE : 259-747-8
• Numéro MDL: MFCD00079020
• Code UNSPSC : 41106305
• ID de substance PubChem : 24892587
• Nomenclature NACRES : NA.51

Propriétés

• Description: cofactor for acyl transfer
• Essai: ≥85% (spectrophotometric assay)
• Forme: powder
• Solubilité: H₂O: soluble 50 mg/mL, clear, colorless to faintly yellow
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
• Clé InChI: SYTRWOCXZXQBPW-CLVRNSBASA-M

Description

Description générale

Coenzyme A (CoA) is an essential cofactor in living systems and is synthesized from pantothenic acid (vitamin B5),[1] The CoA levels in mitochondria and peroxisomes correspond to 2-5 mM and 0.7 mM, respectively. Cytosolic CoA is in the range of 0.05 mM to 0.14 mM[1]

Application

Coenzyme A is suitable for use in:

• gylcerolipid biosynthesis in porcine adipose tissue[2]
• an assay to measure the level of Alpha-methylacyl-CoA racemase (AMACR) in human blood samples using a nanoparticle electrochemical biosensor[3]
• chloramphenicol acetyltransferase (CAT) assay[4][5]
• the synthesis of palmitoyl-CoA, which is required for palmitoylation and activation of proteins for regulated membrane fusion[6]

Actions biochimiques/physiologiques

Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. In the presence of CoASH, organic carboxylic acids form acyl-CoA thioesters, which facilitates enzyme recognition. The acyl-CoA formed from xenobiotic carboxylic acids can add to the compound′s toxicity, which can lead to cellular metabolic dysfunction.[7] It is involved in the oxidation of pyruvate in the Kreb′s cycle. CoA is needed for metabolic events.[8] The bacterial CoA pathway is targeted for antimicrobial development.[8] It mediates acyl group transfer and carbonyl activation. The CoA and its thioester levels are crucial for cellular homeostasis. CoA is also involved in regulating platelet aggregation and vasoconstriction.[1] It acts as an essential cofactor in enzymatic acetyl transfer reactions.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)