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A2862

Sigma-Aldrich

Astilbin from Engelhardtia roxburghiana

≥98%

Synonyme(s) :

Astilbin, Dihydroquercetin 3-rhamnoside, Taxifolin 3-rhamnoside

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About This Item

Formule empirique (notation de Hill):
C21H22O11
Numéro CAS:
29838-67-3
Poids moléculaire :
450.39
Numéro MDL:
MFCD20274680
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.25

Pureté

≥98%

Forme

powder

Solubilité

H2O: 1 mg/mL, clear, colorless

Application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Température de stockage

2-8°C

Chaîne SMILES 

O=C1C2=C(O)C=C(O)C=C2O[C@H](C3=CC(O)=C(O)C=C3)[C@H]1O[C@@]4([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4

InChI

1S/C21H22O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-26,28-29H,1H3/t7-,15-,17+,18+,19-,20+,21-/m0/s1

Clé InChI

ZROGCCBNZBKLEL-MFSALPCASA-N

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Catégories apparentées

Description générale

Astilbin belongs to the class of dihydroflavanol compounds and is the chief biologically active component of Rhizoma Smilacis Glabrae (RSG) extract. RSG is obtained from the dried rhizome of Smilax Glabra Roxb.

Application

Astilbin from Engelhardtia roxburghiana, a flavonoid phytochemical with antibacterial activity, may be used to study its pharmacology and the effects of its antiproliferative activities versus a variety of cell types.

Actions biochimiques/physiologiques

Astilbin exerts various biological activities such as anti-oxidative, anti-bacterial, and inhibition of contact hypersensitivity. Also, it shows insecticidal, anti-oedematogenic, antinociceptive and antidepressant properties. It has an inhibitory effect on the aldose reductase enzyme, the accumulation of sorbitol, and a protective effect on the liver. Astilbin is helpful against autoimmune diseases such as rheumatoid arthritis due to its ability to reduce matrix metalloproteinase (MMP) activity and Nitric oxide production in T lymphocytes.
Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations. Immunosuppresive. Antiproliferative.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Jingqun Huang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(9), 1943-1947 (2011-05-24)
Flavonoids are widely found in plants and many of them possess biological and pharmacological activities. In the present study, we assessed the effects of the flavonoids Genistein, Apigenin, Quercetin, Rutin and Astilbin on xanthine oxidase (XO) activities in vitro, and
O Mezghrani et al.
Die Pharmazie, 66(10), 754-760 (2011-10-27)
The main purpose of this research work was to design an optimized self micro-emulsifying drug delivery system (SMEDDS) to enhance the bioavailability of the poor water soluble drug, astilbin. The solubility of astilbin was evaluated in various vehicles. Pseudoternary phase
Y Cai et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 52(8), 334-340 (2003-09-25)
To examine the therapeutic effects of astilbin, a flavanoid isolated from Rhizoma Smilacis Glabrae, on arthritis and to compare it with cyclosporine A (CsA). Type II collagen-induced arthritis in mice and its in vitro assays for proliferation, matrix metalloproteinase (MMP)
Antioxidant activity of Rhizoma Smilacis Glabrae extracts and its key constituent-astilbin
Zhang QF, et al.,
Food Chemistry, 115(1), 297-303 (2009)
Xi-Cheng He et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(23), 3595-3598 (2013-03-13)
Astilbin in 28 Smilax glabra (red and white cross-section) from different sources was determined by HPLC. Pharmacodynamics and component of S. glabra was investigated through inflammation experiment (penetration type). The analysis was performed on a Hypersil ODS2 column (4.6 mm
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