Unfortunately, the solution stability of this product is not determined. It is recommended to use freshly prepared solutions.
42966
Polymère de l'acide 12-hydroxy-octadécanoïque avec l'α-hydro-ω-hydroxypoly(oxy-1,2-éthanediyl)
Synonyme(s) :
Acide12-hydroxystéarique polyoxyéthylé, Macrogol (15)-hydroxystéarate, Polyéthylène glycol (15)-hydroxystéarate, Solutol® HS 15
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About This Item
Numéro CAS:
Code UNSPSC :
12161900
ID de substance PubChem :
Nomenclature NACRES :
NA.25
Produits recommandés
Description
non-ionic
Forme
paste
Composition
free macrogoly% (27.0 - 39.0 g/100g (%))
Impuretés
acetic acid (≤ 0.5 g/100g (%))
water (≤ 0.5 g/100g (%))
≤0.05% acetic acid
≤0.05% water
≤1 mg/kg ethylene oxide ((ppm))
≤1 mg/kg ethylene oxide
≤1 mg/kg nickel ((ppm))
≤1 mg/kg nickle
≤10 mg/kg dioxane ((ppm))
≤10 mg/kg dioxane
≤10 mg/kg heavy metals
≤620 mg/kg Diethylene glycol
≤620 mg/kg diethylene glycol ((ppm))
≤620 mg/kg ethylene glycol ((ppm))
≤620 mg/kg ethylene glycol
<10 mg/kg heavy metals ((ppm))
Résidus de calcination
(≤ 0.3 g/100g (%))
pH
5.0-7.0 (1 g/10 mL in H2O)
Pf
25 - 30 °C (77 - 86 °F)
Indice d'acide
≤1.0 mg KOH/g
Indice d'hydroxyle
90‑110 mg KOH/g
Indice d'iode
≤2.0 g I2/100 g
Indice de peroxyde
≤3.0 meq/kg
Indice de saponification
53‑63 mg KOH/g
Solubilité
water: 200 g/L at 30 °C (86 °F)
Densité
1.048 g/cm3 at 20 °C (68 °F)
1.03 g/cm3 at 60 °C (140 °F)
Traces d'anions
<1 ppm (Ethylene Oxide)
<10 ppm (Dioxane)
Traces de cations
Ni: <1 ppm
heavy metals: <10 ppm
Application(s)
sample preservation
Chaîne SMILES
C(CCCCC(CCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O)CCCCC(=O)O
InChI
1S/C47H94O19/c48-15-17-53-19-21-55-23-25-57-27-29-59-31-33-61-35-37-63-39-41-65-43-45-66-44-42-64-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-11-7-6-9-13-46(49)12-8-4-2-1-3-5-10-14-47(50)51/h46,48-49H,1-45H2,(H,50,51)
Clé InChI
CYAMZYIUAHNTBO-UHFFFAOYSA-N
Catégories apparentées
Description générale
Le polymère de l'acide 12-hydroxy-octadécanoïque avec l'α-hydro-ω-hydroxypoly(oxy-1,2-éthanediyl) est un tensioactif non ionique indépendant du pH qui constitue un solubilisant et un agent émulsifiant efficace. Il est soluble dans les milieux aqueux et les solvants organiques polaires, mais n'est pas soluble dans les solvants apolaires. Sa structure est composée d'acide 12-hydroxystéarique (fraction lipophile) et de polyéthylène glycol (fraction hydrophile).
Application
- Le polymère de l'acide 12-hydroxy-octadécanoïque avec l'α-hydro-ω-hydroxypoly(oxy-1,2-éthanediyl) a été utilisé :
- pour dissoudre de la dexaméthasone (DEX) en vue de son injection intrapéritonéale chez des souris pour tester leur force de préhension et mesurer leur force musculaire.
- dans une préparation de roflumilast destinée à traiter des lapins et des cochons d'Inde afin d'étudier les mécanismes et la sensibilité pharmacologique des réponses hypertussives induites par l'ozone.
- pour dissoudre de la finérénone en vue de son application par voie orale dans le cadre d'études in vivo.
Actions biochimiques/physiologiques
Le polymère de l'acide 12-hydroxy-octadécanoïque avec l'α-hydro-ω-hydroxypoly(oxy-1,2-éthanediyl) est principalement utilisé comme solubilisant dans les formulations administrées par voies orale et parentérale. C'est le composé privilégié pour les études de criblage in vitro et les études d'efficacité des composés in vivo. Le polymère de l'acide 12-hydroxy-octadécanoïque avec l'α-hydro-ω-hydroxypoly(oxy-1,2-éthanediyl) est également utilisé dans les formulations ophtalmiques, de macromolécules, de suppositoires et de protéines en raison de ses caractéristiques de solubilisation et de son profil d'innocuité. Il peut former des micelles d'une taille typique de 10-15 nm. Le polymère de l'acide 12-hydroxy-octadécanoïque avec l'α-hydro-ω-hydroxypoly(oxy-1,2-éthanediyl) peut être utilisé pour développer des formulations pour administration intraveineuse sous forme de micro-émulsion.
Autres remarques
Le polymère de l'acide 12-hydroxy-octadécanoïque avec l'α-hydro-ω-hydroxypoly(oxy-1,2-éthanediyl) est un détergent non ionique obtenu en faisant réagir 15 moles d'oxyde d'éthylène avec 1 mole d'acide 12-hydroxystéarique.
Pour de plus amples informations sur notre gamme de Produits biochimiques, merci de compléter ce formulaire.
Informations légales
Solutol is a registered trademark of BASF SE
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A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance of KB 8-5 and KB 8-5-11 human epidermoid carcinoma cells in vitro but
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Hi how do you store solutol ? at RT, it solidifies
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Hi, What is the recommended storage condition for Kolliphor HS 15 and what is the expected shelf life corresponding the storage condition? Thank you!
1 answer-
This product can be stored at room temperature. Products that are robust in nature and extremely stable, in the original unopened container, are not assigned an expiration date or retest schedule. These products will have no dating reported on either the label or the Certificate of Analysis.
Products that are not assigned an expiration or retest date are covered by a warranty period of 1 year from the date of product shipment.
Full Product Dating Information may be reviewed at the link below: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/190/408/product-dating-information-ms.pdf
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Hi; please, can i have the spectrum IR of macrogol-15-hydroxystearate (lot BBCH6204); best regard.
1 answer-
The attached brochure and attributes table details the M-Clarity™ Program, and the discriminating quality elements for each product level: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/400/043/clarity-program-brochure-br3925en-mk.pdf
https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma-Aldrich/General_Information/2/M-Clarity_attributes_table_mk.pdfThe product is marketed as level M-Clarity™ MQ100, MQ200, or MQ300, and as such, does not offer analytical method information (batch testing information / “for-cost” testing). Such a service is offered on products marketed as M-Clarity™ MQ400, and above. For questions regarding M-Clarity™ Program or other product detail, please navigate to the link https://www.sigmaaldrich.com/techservice, click on "Product Technical Inquiries" under the Products Section with all the required information so that a member of the Technical Service team can reach out to assist further. Thank you.
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