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Principaux documents

42965

Sigma-Aldrich

Tramadol hydrochloride

≥99.0% (HPLC)

Synonyme(s) :

Tramadol HCl, (±)-cis-2-(Dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexanol hydrochloride

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About This Item

Formule empirique (notation de Hill):
C16H25NO2 · HCl
Numéro CAS:
Poids moléculaire :
299.84
Numéro CE :
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.25
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Essai

≥99.0% (HPLC)

Forme

powder

Contrôle du médicament

USDEA Schedule IV

Pf

178-181 °C

Chaîne SMILES 

Cl.COc1cccc(c1)[C@@]2(O)CCCC[C@@H]2CN(C)C

InChI

1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m1./s1

Clé InChI

PPKXEPBICJTCRU-XMZRARIVSA-N

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Application

Tramadol hydrochloride has been used to study the tramadol biosynthesis route in plants.[1]

Actions biochimiques/physiologiques

Tramadol hydrochloride (HCl) inhibits the reuptake of norepinephrine and serotonin in μ-opioid receptors in rat models in vitro.[2][3]
Opioid analgesic; P450 substrate.

Pictogrammes

Skull and crossbonesEnvironment

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Acute Tox. 3 Oral - Aquatic Chronic 2 - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Consulter la Bibliothèque de documents

Howard S Smith
Mayo Clinic proceedings, 84(7), 613-624 (2009-07-02)
Clinicians understand that individual patients differ in their response to specific opioid analgesics and that patients may require trials of several opioids before finding an agent that provides effective analgesia with acceptable tolerability. Reasons for this variability include factors that
B Driessen et al.
British journal of pharmacology, 108(3), 806-811 (1993-03-01)
1. The centrally acting analgesic, tramadol, has low affinity for opioid receptors and therefore presumably other mechanisms of analgesic action. Neurotransmitter release and uptake experiments were used to characterize the effects of tramadol on the central noradrenergic and dopaminergic systems.
Arshi Kizilbash et al.
Journal of pain research, 7, 149-161 (2014-04-09)
Patients with chronic non-malignant pain report impairments of physical, social, and psychological well-being. The goal of pain management should include reducing pain and improving quality of life. Patients with chronic pain require medications that are able to provide adequate pain
Emrah Yuruk et al.
Journal of endourology, 29(4), 463-467 (2014-10-01)
To compare the outcomes of these minimally invasive procedures in this patient population. The database of our institution has been retrospectively reviewed, and medical records of urolithiasis patients with a solitary kidney who underwent flexible ureteroscopy (F-URS) or extracorporeal shock
Katarzyna M Romek et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8296-8301 (2015-06-25)
Tramadol, previously only known as a synthetic analgesic, has now been found in the bark and wood of roots of the African medicinal tree Nauclea latifolia. At present, no direct evidence is available as to the biosynthetic pathway of its

Questions

  1. we have sealed vial of tramadol hydrochloride 42695 lot number BBCBV6194. its quality relase date is 02 AUG 2017. the vial is sealed and kept in room temperature. how long this would be valid for use

    1 answer
    1. This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

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