PHR1045
Diethylene glycol
Pharmaceutical Secondary Standard; Certified Reference Material
Synonyme(s) :
2,2′-oxydiéthanol, 2-hydroxyéthyl éther
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About This Item
Formule linéaire :
(HOCH2CH2)2O
Numéro CAS:
Poids moléculaire :
106.12
Numéro Beilstein :
969209
Numéro CE :
Numéro MDL:
Code UNSPSC :
41116107
ID de substance PubChem :
Nomenclature NACRES :
NA.24
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Qualité
certified reference material
pharmaceutical secondary standard
Niveau de qualité
Agence
traceable to Ph. Eur. Y0000217
traceable to USP 1193265
Densité de vapeur
2.14 (vs air)
Pression de vapeur
0.01 mmHg ( 20 °C)
Famille d'API
diethylene glycol
CofA (certificat d'analyse)
current certificate can be downloaded
Température d'inflammation spontanée
442 °F
Limite d'explosivité
2-12.3 %
Technique(s)
HPLC: suitable
gas chromatography (GC): suitable
Indice de réfraction
n20/D 1.447 (lit.)
Point d'ébullition
245 °C (lit.)
Pf
−10 °C (lit.)
Densité
1.118 g/mL at 25 °C (lit.)
Application(s)
cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)
Format
neat
Température de stockage
2-30°C
Chaîne SMILES
OCCOCCO
InChI
1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2
Clé InChI
MTHSVFCYNBDYFN-UHFFFAOYSA-N
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Description générale
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.
Application
Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC). It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Remarque sur l'analyse
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Autres remarques
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Note de bas de page
To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive.
Produits recommandés
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Application
Réf. du produit
Description
Tarif
Produit(s) apparenté(s)
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 4 Oral
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
280.4 °F - closed cup
Point d'éclair (°C)
138 °C - closed cup
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Les clients ont également consulté
Identification and quantification of diethylene glycol in pharmaceuticals implicated in poisoning epidemics: an historical laboratory perspective
Bar.BD, et al.
Journal of Analytical Toxicology, 31(6), 295-303 (2007)
Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol
Ferrari.AL and Giannuzzi L
Forensic Science International, 153, 45-51 (2005)
Gas-chromatographic determination of ethylene glycol in serum
Porter H.W and Auansakul aA
Clinical Chemistry, 28, 75-78 (1982)
Tao Zhou et al.
Journal of separation science, 30(16), 2620-2627 (2007-09-21)
A simple and reliable HPLC method was developed for the simultaneous quantitative analysis of diethylene glycol (DEG) and propylene glycol (PG) in pharmaceutical products by precolumn derivatization. The derivatization reagent p-toluenesulfonyl isocyanate (TSIC, 10 microL, 20% in ACN v/v) was
Ze-Jian Wang et al.
Journal of photochemistry and photobiology. B, Biology, 115, 16-24 (2012-07-17)
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