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N0750000

Nifedipine

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester

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About This Item

Formule empirique (notation de Hill):
C17H18N2O6
Numéro CAS:
21829-25-4
Poids moléculaire :
346.33
Numéro MDL:
MFCD00057326
Code UNSPSC :
41116107
ID de substance PubChem :
329818455
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

nifedipine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

COC(=O)C1=C(C)NC(C)=C(C1c2ccccc2[N+]([O-])=O)C(=O)OC

InChI

1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3

Clé InChI

HYIMSNHJOBLJNT-UHFFFAOYSA-N

Informations sur le gène

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nifedipine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Conseils de prudence

P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

Sorry, we don't have COAs for this product available online at this time.

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Oxidized Nifedipine powder, ~95% (HPLC)

Sigma-Aldrich

UC167

Oxidized Nifedipine

Nisoldipine ≥98% (HPLC)

Sigma-Aldrich

N0165

Nisoldipine

Isradipine ≥98% (HPLC), solid

Sigma-Aldrich

I6658

Isradipine

8-Quinolinol ACS reagent, 98.5%

Sigma-Aldrich

252565

8-Quinolinol

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Journal of the American Society of Nephrology : JASN, 24(1), 31-36 (2012-12-18)
Arterial stiffness and impaired nitric oxide (NO) bioavailability contribute to the high risk for cardiovascular disease in CKD. Both asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO production, and endothelin-1 (ET-1) oppose the actions of NO, suggesting that ET-1 receptor
Joel S Klinck et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 157(2), 236-250 (2012-12-04)
Transport of calcium (Ca) and cadmium (Cd) was examined along the gastro-intestinal tract (GIT) of freshwater and seawater Oncorhynchus mykiss irideus (FWT and SWTies respectively) using in vitro and in vivo experiments. Based on known physiological differences between FWT and
Carolien Roos et al.
JAMA, 309(1), 41-47 (2013-01-03)
In threatened preterm labor, maintenance tocolysis with nifedipine, after an initial course of tocolysis and corticosteroids for 48 hours, may improve perinatal outcome. To determine whether maintenance tocolysis with nifedipine will reduce adverse perinatal outcomes due to premature birth. APOSTEL-II
Yui Yamamoto et al.
Journal of pharmacological sciences, 121(3), 212-226 (2013-03-02)
We recently developed a novel cognitive enhancer, ST101 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one), that activates T-type voltage-gated calcium channels (VGCCs). Here, we address whether T-type VGCC activation with ST101 mediates its cognitive effects in vivo and the relevance of T-type VGCC activation to acetylcholine
Corey B Toal et al.
Blood pressure, 21 Suppl 1, 3-10 (2012-07-06)
Calcium-channel blockers (CCBs) constitute a diverse group of compounds but are often referred to as a single homogeneous class of drug and the clinical responses indiscriminately summarized. Even within the dihydropyridine subgroup, there are significant differences in formulations, pharmacokinetics, durations
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