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M0513

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Megestrol acetate

analytical standard, for drug analysis

Synonyme(s) :

17α-acétoxy-6-méthyl-4,6-pregnadiène-3,20-dione, 17α-hydroxy-6-méthyl-4,6-pregnadiène-3,20-dione 17-acétate

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About This Item

Formule empirique (notation de Hill):
C24H32O4
Numéro CAS:
595-33-5
Poids moléculaire :
384.51
Numéro Beilstein :
1917291
Numéro CE :
209-864-5
Numéro MDL:
MFCD00056470
Code UNSPSC :
41116107
ID de substance PubChem :
329817798
Nomenclature NACRES :
NA.24

Qualité

analytical standard, for drug analysis

Niveau de qualité

100

Pureté

≥99% (HPLC)

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
veterinary

Format

neat

Chaîne SMILES 

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@]3(OC(C)=O)C(C)=O)[C@]1([H])C=C(C)C4=CC(=O)CC[C@]24C

InChI

1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1

Clé InChI

RQZAXGRLVPAYTJ-GQFGMJRRSA-N

Informations sur le gène

human ... PGR(5241)

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Description générale

Megestrol acetate is a commonly used synthetically prepared glucosteroid, which possesses anti-inflammatory property.

Application

Megestrol acetate may be used as a reference standard for the determination of megestrol acetate in human serum using reversed-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogrammes

Health hazard
GHS08

Mention d'avertissement

Danger

Mentions de danger

H360FD

Classification des risques

Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number
087H0250V
087H0250
087H0250
099F0453
084F0209

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Consulter la Bibliothèque de documents

Determination of megestrol acetate and cyproterone acetate in serum of patients with advanced breast cancer by high-performance liquid chromatography
Dikkeschei.D.L, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 529, 145-154 (1990)
Handbook of Clinical Nutrition and Aging (2009)
Yo Han Kim et al.
Clinical therapeutics, 37(2), 439-447 (2014-12-03)
Megestrol acetate oral suspension is an appetite stimulant indicated for cachexia. It is available in a conventional formulation and as a nanocrystal dispersion. The aim of this study was to compare the tolerability and pharmacokinetics of these formulations under fed
Navdha Mittal et al.
PloS one, 9(10), e110410-e110410 (2014-10-24)
Resistance to progestin treatment is a major hurdle in the treatment of advanced and reoccurring endometrial cancer. Fenretinide is a synthetic retinoid that has been evaluated in clinical trials as a cancer therapeutic and chemo-preventive agent. Fenretinide has been established
Francisco J Prado-Prado et al.
Bioorganic & medicinal chemistry, 18(6), 2225-2231 (2010-02-27)
There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one parasite species. Consequently, predicting the probability with which a drug is active against
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