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Phosphonoacetic acid

TraceCERT®, 31P-qNMR Standard, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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About This Item

Formule linéaire :
(HO)2P(O)CH2CO2H
Numéro CAS:
4408-78-0
Poids moléculaire :
140.03
Numéro CE :
224-558-1
Numéro MDL:
MFCD00004311
Code UNSPSC :
41116107
ID de substance PubChem :
329770527
Nomenclature NACRES :
NA.24

Niveau de qualité

300

Gamme de produits

TraceCERT®

Qualité

TraceCERT®

Forme

solid

Durée de conservation

limited shelf life, expiry date on the label

Fabricant/nom de marque

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Technique(s)

qNMR: suitable

Pf

143-146 °C (lit.)

Application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical

Chaîne SMILES 

OC(=O)CP(O)(O)=O

InChI

1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)

Clé InChI

XUYJLQHKOGNDPB-UHFFFAOYSA-N

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Catégories apparentées

Description générale

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.


Check out our entire range of quantitative NMR standards (qNMR standards)

Application


  • Enhancing Guide RNA Stability and Editing Yields: Phosphonoacetate modifications have been shown to significantly enhance the stability and editing efficiency of guide RNAs for Cas9-based genome editors. This development has profound implications in genetic engineering and therapeutic applications, where precision and stability are crucial (Ryan et al., 2023).

  • Glomerular and Tubulointerstitial Nephropathy Study: Phosphonoacetic acid has been indirectly related to studies on kidney diseases such as glomerular and tubulointerstitial nephropathy, showcasing its potential relevance in medical research to understand and treat complex renal conditions (Pleško et al., 2021).

  • Environmental Impact of Phosphonoacetate: Research on PMIDA-modified magnetic nanoparticles, including those related to phosphonoacetate, explores their application in liver MRI, indicating its utility in enhancing diagnostic imaging techniques and its potential environmental implications (Demin et al., 2018).

  • CRISPR-Cas Specificity Improvement: Modifications including phosphonoacetate derivatives have been employed to improve the specificity and efficiency of CRISPR-Cas systems in gene editing, underscoring the chemical′s role in cutting-edge biotechnological research (Ryan et al., 2018).

  • Cardiovascular Pharmacology: Studies involving phosphonoacetic acid have been connected to cardiovascular pharmacology, particularly in exploring the mechanisms that inhibit calcification in vascular tissues, which is vital for developing treatments for vascular calcification diseases (Duan et al., 2017).

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Informations légales

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Choose from one of the most recent versions:

Certificats d'analyse (COA)

Lot/Batch Number
BCCL4671
BCCJ6601
BCCD8577
BCCD1557
BCBS6034V

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Weber, M., Hellriegel, C., Rueck, A., Sauermoser, R., and Wuethrich, J.
Accreditation and Quality Assurance, 18, 91-98 (2013)
Michael Weber et al.
Analytical and bioanalytical chemistry, 407(11), 3115-3123 (2014-11-25)
Quantitative nuclear magnetic resonance (qNMR) spectroscopy is employed by an increasing number of analytical and industrial laboratories for the assignment of content and quantitative determination of impurities. Within the last few years, it was demonstrated that (1)H qNMR can be
Michael Weber et al.
Journal of pharmaceutical and biomedical analysis, 93, 102-110 (2013-11-05)
Quantitative NMR spectroscopy (qNMR) is gaining interest across both analytical and industrial research applications and has become an essential tool for the content assignment and quantitative determination of impurities. The key benefits of using qNMR as measurement method for the

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