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410225

Sigma-Aldrich

Glycine

≥98.5%, ACS reagent for peptide synthesis

Synonyme(s) :

Acide aminoacétique, Acide aminoéthanoïque, Glycocolle

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50 G
63,40 $
250 G
212,00 $

About This Item

Formule linéaire :
NH2CH2COOH
Numéro CAS:
56-40-6
Poids moléculaire :
75.07
Beilstein:
635782
Numéro CE :
200-272-2
Numéro MDL:
MFCD00008131
Code UNSPSC :
12352209
eCl@ss :
32160406
ID de substance PubChem :
24865701
Nomenclature NACRES :
NA.21

63,40 $

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Nom du produit

Glycine, ACS reagent, ≥98.5%

Qualité

ACS reagent

Niveau de qualité

200

Essai

≥98.5%

Forme

powder, crystals or granules

Impuretés

H2SO4, passes test (darkened)
 Hydrolyzable subsances, passes test

Résidus de calcination

≤0.1%

Couleur

white

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

Pf

240 °C (dec.) (lit.)

Traces d'anions

chloride (Cl-): ≤0.005%
sulfate (SO42-): ≤0.005%

Traces de cations

NH4+: ≤0.005%
heavy metals: ≤0.002% (by ICP)

Application(s)

peptide synthesis

Groupe fonctionnel

amine
carboxylic acid

Chaîne SMILES 

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

Clé InChI

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Informations sur le gène

rat ... Grin2a(24409)

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Catégories apparentées

Description générale

Glycine is the simplest amino acid building block.

Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents.[1] It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.[2]

Actions biochimiques/physiologiques

Glycine is a non-essential amino acid.[3] Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors.[4] Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.[3]
Neurotransmetteur inhibiteur de la moelle épinière, régulateur allostérique des récepteurs du NMDA.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000227762
0000227734
0000175691
0000251234
0000266202

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A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies
Heba Ahmed
Advanced Materials, 30(3) (2018)
Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View
Vinita Jagannath
Frontiers in Molecular Neuroscience (2017)
Amino acids: metabolism, functions, and nutrition
Guoyao Wu
Amino Acids, 37(1), 1-17 (2009)
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
Mohit Jain
Science, 336(6084), 1040-1044 (2012)
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
Afficher tous les articles scientifiques apparentés

Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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