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Sigma-Aldrich

Glycine

puriss. p.a., reag. Ph. Eur., buffer substance, 99.7-101% (calc. to the dried substance)

Synonyme(s) :

Acide aminoacétique, Acide aminoéthanoïque, Glycocolle

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About This Item

Formule linéaire :
NH2CH2COOH
Numéro CAS:
56-40-6
Poids moléculaire :
75.07
Numéro Beilstein :
635782
Numéro CE :
200-272-2
Numéro MDL:
MFCD00008131
Code UNSPSC :
12352209
eCl@ss :
32160406
ID de substance PubChem :
57648780
Nomenclature NACRES :
NA.21

Agence

USP/NF
reag. Ph. Eur.

Niveau de qualité

200

Qualité

puriss. p.a.

Pureté

99.7-101% (calc. to the dried substance)

Forme

crystalline powder

Technique(s)

IR spectroscopy: suitable

Impuretés

≤0.001% heavy metals (as Pb)
≤0.02% ammonium (NH4)
≤0.1% water (Karl Fischer)
≤1.0% ninhydrin-positive substances

Résidus de calcination

≤0.05% (as SO4)

Perte

≤0.5% loss on drying, 105°C, 2 h

pH

5.9-6.4 (20 °C, 5%)

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

Pf

240 °C (dec.) (lit.)

Traces d'anions

chloride (Cl-): ≤30 mg/kg
sulfate (SO42-): ≤20 mg/kg

Traces de cations

Fe: ≤5 mg/kg

Adéquation

in accordance for identity (IR)

Chaîne SMILES 

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

Clé InChI

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Informations sur le gène

rat ... Grin2a(24409)

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Application

Glycine can be used as:
  • A reactant in the natural soil clay-catalyzed cleavage and polycondensation with pyrogallol.
  • A catalyst in the Knoevenagel reaction between aryl aldehydes and malononitrile to form a C=C bond.
  • A reagent in the metal-free synthesis of biaryls from aryl sulfoxides and sulfonanilides via sigmatropic rearrangement.

Actions biochimiques/physiologiques

Neurotransmetteur inhibiteur de la moelle épinière, régulateur allostérique des récepteurs du NMDA.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
STBL3196
STBH1301
STBL1005
STBK8902
STBK7479

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Richard A Felix et al.
Brain structure & function, 220(5), 2639-2652 (2014-06-30)
The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
Li-Chun Tu et al.
The EMBO journal, 32(24), 3220-3230 (2013-11-12)
Nuclear pore complexes (NPCs) mediate cargo traffic between the nucleus and the cytoplasm of eukaryotic cells. Nuclear transport receptors (NTRs) carry cargos through NPCs by transiently binding to phenylalanine-glycine (FG) repeats on intrinsically disordered polypeptides decorating the NPCs. Major impediments
Suzanne L Grant et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 844(2), 278-282 (2006-08-08)
A simple and versatile methodology using high-performance liquid chromatography (HPLC) with fluorimetric detection was developed to simultaneously determine d-serine along with other metabolically related neuroactive amino acids in the glutamatergic system: L-serine, L-glutamate, L-glutamine, and glycine. On-column sensitivity was in
Zoé Husson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9418-9431 (2014-07-11)
The principal neurons of the cerebellar nuclei (CN), the sole output of the olivo-cerebellar system, receive a massive inhibitory input from Purkinje cells (PCs) of the cerebellar cortex. Morphological evidence suggests that CN principal cells are also contacted by inhibitory
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