ABE606

Anti-PERP Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : p53 apoptosis effector related to PMP-22, PERP, Keratinocyte-associated protein 1, KCP-1, Krtcap1
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: human
• Technique(s): immunocytochemistry: suitable; western blot: suitable
• Numéro d'accès UniProt: A6NN79
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PERP(64065)

Description

Description générale

P53 apoptosis effector related to PMP-22 (PERP), also known as Keratinocyte-associated protein 1 (KCP-1, Krtcap1), is a member of the TMEM47 family and a component of the intercellular desmosome junctions. PERP has been shown to play an important role in the stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Recent evidence implies that PERP is a mediator of p53 induced apoptosis. P53 binds to the promoter of PERP and activates the PERP gene and consequently the translated PERP protein mediates the p53 induced apoptosis. PERP is expressed in apoptotic cells and in the stratified squamous skin epithelium of the skin and the tongue, but not in simple epithelia.

Immunogène

KLH-conjugated linear peptide corresponding to human PERP.

Application

Detect P53 apoptosis effector related to PMP-22 using this rabbit polyclonal antibody, Anti-PERP Antibody validated for use in western blotting & ICC.

Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected PERP in A431 cells.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
RNA Metabolism & Binding Proteins

Qualité

Evaluated by Western Blotting/Peptide Inhibition Assay in A431 cell lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected PERP in 15 µg of A431 cell lysate.

Description de la cible

~21 kDa observed. Uncharacterized bands may appear in some lysate(s).

Forme physique

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
A431 cell lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable