648450-M

TrkA Inhibitor

The TrkA Inhibitor, also referenced under CAS 388626-12-8, controls the biological activity of TrkA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : TrkA Inhibitor
• Formule empirique (notation de Hill): C₁₅H₁₃N₃O₃S
• Numéro CAS: 388626-12-8
• Poids moléculaire : 315.35
• Code UNSPSC : 12352200

Propriétés

• Pureté: ≥97% (sum of two isomers, HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 200 mg/mL
• Température de stockage: 2-8°C

Description

Description générale

A potent, cell-permeable, reversible, and highly selective inhibitor of TrkA (IC₅₀ = 63 nM), presumably by targeting the ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

An oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC₅₀ = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.

Actions biochimiques/physiologiques

Primary Target
TrkA

Target IC₅₀: 63 nM against TrkA

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett.14, 953.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable