5.05278

PNU 282987

• Synonyme(s) : PNU 282987, PNU-282987, N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide hydrochloride, α7 nAChR Agonist, PNU 282987, alpha 7 Nicotinic Acetylcholine Receptor Agonist, PNU 282987, PNU282987
• Formule empirique (notation de Hill): C₁₄H₁₇ClN₂O · xHCl
• Numéro CAS: 123464-89-1
• Poids moléculaire : 264.75 (free base basis)
• Code UNSPSC : 12352200

Propriétés

• Essai: ≥99% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Puissance: 26 nM K_i
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: water: 100 mM
• Température de stockage: 2-8°C
• InChI: 1S/C14H17ClN2O.ClH/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17;/h1-4,10,13H,5-9H2,(H,16,18);1H/t13-;/m0./s1
• Clé InChI: HSEQUIRZHDYOIX-ZOWNYOTGSA-N

Description

Description générale

A potent agonist highly selective for α7 nAChRs (K_i = 26 nM). Used in investigating the roles of α7 nAChRs in sensory gating, learning and memory, cognitive functions, and treatment of Schizophrenia.

Actions biochimiques/physiologiques

Primary Target
α7 nAChRs

Reversible: yes

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Hajós, M., et al., 2010, Curr. Pharm. Des.16, 538.
Bodnar, L., et al., 2005. J. Med. Chem.48, 905.
Hajós, M., et al., 2005. J. Pharmacol. Exp. Ther.312, 1213.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3