5.04840

(R)-CPPene

• Synonyme(s) : (R)-CPPene, (R)-4-[(2E)-3-Phosphono-2-propenyl]-2-piperazinecarboxylic acid, SDZ EAA 494, Midafotel
• Formule empirique (notation de Hill): C₈H₁₅N₂O₅P
• Numéro CAS: 117414-74-1
• Poids moléculaire : 250.19
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥99% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: H₂O: 100 mM
• Température de stockage: 2-8°C
• InChI: 1S/C8H15N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h1,5,7,9H,2-4,6H2,(H,11,12)(H2,13,14,15)/b5-1+/t7-/m1/s1
• Clé InChI: VZXMZMJSGLFKQI-ABVWVHJUSA-N

Description

Description générale

A highly potent competitive antagonist of NMDA receptors (ED₅₀ = 39 nM; pA2 = 6.8). Biologically active admitted systemically. Frequently used in assessing the functional roles of NMDA receptors mediated neurotransmissions in a variety of research areas, such as excitotoxic cell death, apoptosis, bipolar disorders, ischemia, traumatic brain injury, epilepsy, and neuropathic pain.

Actions biochimiques/physiologiques

Primary Target
NMDA receptors

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Lowe, D., et al. 1990. Neurosci. Lett.113, 315.
Bullock, R., et al. 1990. Stroke.21, 32.
Bespalov, A., et al. 1998. Eur. J. Pharmacol.351, 299.

Lowe, D., et al. 1994. Neurochem. Inter.25, 583.
Duty, S. 2012. CNS Drugs26, 1017.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable