14-595-M
PP1α Protein, 10 µg
Recombinant, full length, human PP1α, for use in Phosphatase Assays.
Synonyme(s) :
PPP1C, Phosphoprotein phosphatase 1, Phosphorylase phosphatase
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About This Item
Code UNSPSC :
12352200
eCl@ss :
32160405
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in E. coli
Forme
solution
Durée de conservation
6 mo.
Poids mol.
Mw 37.6 kDa
Fabricant/nom de marque
Upstate®
Technique(s)
activity assay: suitable (phosphatase)
Solubilité
water: soluble
Numéro d'accès NCBI
Numéro d'accès UniProt
Température de stockage
−20°C
Informations sur le gène
human ... PPP1CA(5499)
Description générale
Research area: Neuroscience
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.
Application
Research Category
Inflammation & Immunology
Inflammation & Immunology
Actions biochimiques/physiologiques
Protein Target: PP1α Target Sub-Family: Ser/Thr phosphatase
Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.
Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.
Conditionnement
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-595M when ordering the 250 µg size.
Qualité
routinely evaluated by dephosphorylation of 100μM DiFMUP
Forme physique
Heparin agarose followed by Q agarose
Stockage et stabilité
6 months at -20°C from date of shipment
Autres remarques
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Skin Sens. 1
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity.
Munton, Richard P, et al.
Febs Letters, 567, 121-128 (2004)
Modulation of dendritic spines by protein phosphatase-1
Advances in Pharmacology, 90.0, 117-144 (2021)
Alphonse Garcia et al.
Biochimie, 85(8), 721-726 (2003-10-31)
The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of
Targeting phosphatases as the next generation of disease modifying therapeutics for Parkinson?s disease
Braithwaite SP, et al.
Neurochemistry International, 61, 899-906 (2012)
Karl Foley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(14), 3040-3050 (2021-04-09)
Protein phosphatases, by counteracting protein kinases, regulate the reversible phosphorylation of many substrates involved in synaptic plasticity, a cellular model for learning and memory. A prominent phosphatase regulating synaptic plasticity and neurologic disorders is the serine/threonine protein phosphatase 1 (PP1).
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