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04-299

Sigma-Aldrich

Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3

clone 10C3, Upstate®, from mouse

Synonyme(s) :

INSR

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

10C3, monoclonal

Espèces réactives

human

Fabricant/nom de marque

Upstate®

Technique(s)

activity assay: suitable
western blot: suitable

Isotype

IgG1

Numéro d'accès NCBI

NM_000208.2
NM_001079817.1

Numéro d'accès UniProt

P06213

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

phosphorylation (pTyr1150/pTyr1151)

Informations sur le gène

human ... INSR(3643)

Spécificité

Recognizes phosphorylated domain of Insulin receptor on Tyrosine 1150/1151.

Immunogène

KLH-conjugated synthetic peptide encompassing the surrounding amino acids of Tyrosine 1150/1151 on phosphorylated insulin receptor.

Application

Detect phospho-Insulin Receptor (Tyr 1150/1151) using this Anti-phospho-Insulin Receptor (Tyr 1150/1151) Antibody, clone 10C3 validated for use in EA & WB.

Qualité

Routinely evaluated by immunoblot.

Description de la cible

97 kDa

Forme physique

Format: Purified
In 1 mL of PBS containing 0.09% sodium azide, PEG, and sucrose and 50% glycerol.

Remarque sur l'analyse

Control
Includes pervanadate treated HEK293 lysate as a positive control

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

10 - Combustible liquids

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Natalie N Rizk et al.
Fertility and sterility, 86(4 Suppl), 1217-1222 (2006-09-12)
To determine whether the insulin receptor (IR), insulin-like growth factor-I receptor (IGF-IR), and IGF-I are expressed differentially in fibroblasts isolated from normal peritoneal and adhesion tissue before and after 24-hour treatment with increasing glucose concentrations. Prospective experimental study. University medical
Qiu-yan Wang et al.
The FEBS journal, 274(2), 526-538 (2007-01-19)
Two H7721 human hepatocarcinoma cell lines showing moderate and high expression of alpha1,3-fucosyltransferase (FucT)-VII cDNA were established and designated FucTVII-M and FucTVII-H, respectively. In alpha1,3-FucT-VII-transfected cells, expression of insulin receptor (InR) alpha- and beta subunits and epidermal growth factor receptor
Rita Slaaby et al.
The Journal of biological chemistry, 281(36), 25869-25874 (2006-07-13)
Insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) are both from the same subgroup of receptor tyrosine kinases that exist as covalently bound receptor dimers at the cell surface. For both IR and IGF-IR, the most described forms
Atsumi Tsuji-Hosokawa et al.
Pediatric diabetes, 18(8), 917-924 (2017-02-10)
Defects of the insulin receptor gene ( INSR ) cause wide spectra of congenital insulin resistance. Monoallelic defects result in milder insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN, type A). Whereas, leprechaunism (Donahue syndrome), the most severe condition with lethality
Adrián Martín-Segura et al.
Aging cell, 18(3), e12932-e12932 (2019-03-19)
In the brain, insulin plays an important role in cognitive processes. During aging, these faculties decline, as does insulin signaling. The mechanism behind this last phenomenon is unclear. In recent studies, we reported that the mild and gradual loss of
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