860514P

C14 Ceramide (d18:1/14:0)

Avanti Research^™ - A Croda Brand 860514P, powder

• Synonyme(s) : N-myristoyl-D-erythro-sphingosine
• Formule empirique (notation de Hill): C₃₂H₆₃NO₃
• Numéro CAS: 123408-74-2
• Poids moléculaire : 509.85
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Forme: powder
• Conditionnement: pkg of 1 × 25 mg (860514P-25mg); pkg of 1 × 5 mg (860514P-5mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand 860514P
• Type de lipide: sphingolipids
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: OC[C@]([H])(NC(CCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C32H63NO3/c1-3-5-7-9-11-13-15-16-18-19-21-23-25-27-31(35)30(29-34)33-32(36)28-26-24-22-20-17-14-12-10-8-6-4-2/h25,27,30-31,34-35H,3-24,26,28-29H2,1-2H3,(H,33,36)/b27-25+/t30-,31+/m0/s1
• Clé InChI: ZKRPGPZHULJLKJ-JHRQRACZSA-N

Description

Description générale

Ceramide synthesis is majorly driven by de novo pathway involving the palmitoyl-CoA and L-serine, and also by salvage pathway via recycling of complex sphingolipids. The ceramide transporter, Cert mediates the transfer of C14 from smooth endoplasmic reticulum to Golgi. Ceramide synthase CerS6 enzyme is involved in the synthesis of C14 ceramide.

Application

C14 Ceramide (d18:1/14:0) is suitable for use

• as a standard in high-performance liquid chromatography/tandem mass spectrometry (LC/MS²) for ceramide quantification from muscel biopsies
• in lipid monolayer preparation for biophysical studies
• in the morphological and dimensional evaluation studies

Actions biochimiques/physiologiques

Ceramides regulate biological processes including proliferation, differentiation and apoptosis. In the cystic fibrosis patients, elevated levels of C14 ceramide is observed. It is also a potential biomarker for hepatic steatosis (HS) and C14 ceramide levels correlate with the aspartate aminotransferase (AST) / alanine transaminase (ALT) ratio. Tumor necrosis factor α (TNFα) mediates increase in the C14 levels. Fumonisin B1 prevents the C14 accumulation.

Conditionnement

5 mL Amber Glass Screw Cap Vial (860514P-25mg)

5 mL Amber Glass Screw Cap Vial (860514P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids