- Molecular hybridization conceded exceptionally potent quinolinyl-oxadiazole hybrids through phenyl linked thiosemicarbazide antileishmanial scaffolds: In silico validation and SAR studies.
Molecular hybridization conceded exceptionally potent quinolinyl-oxadiazole hybrids through phenyl linked thiosemicarbazide antileishmanial scaffolds: In silico validation and SAR studies.
Bioorganic chemistry (2017-02-24)
Muhammad Taha, Nor Hadiani Ismail, Muhammad Ali, Umer Rashid, Syahrul Imran, Nizam Uddin, Khalid Mohammed Khan
PMID28228228
RESUMO
The high potential of quinoline containing natural products and their derivatives in medicinal chemistry led us to discover a novel series of compounds 6-23 based on the concept of molecular hybridization. Most of the synthesized analogues exhibited potent leishmanicidal potential. The most potent compound (23, IC
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Meio RPMI-1640, HEPES Modification, With 25 mM HEPES, without L-glutamine., liquid, sterile-filtered, suitable for cell culture
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Meio de Schneider para insetos, With L-glutamine and sodium bicarbonate, liquid, sterile-filtered, suitable for insect cell culture