Pular para o conteúdo
Merck
  • Ag(I)-catalyzed aminofluorination of alkynes: efficient synthesis of 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.

Ag(I)-catalyzed aminofluorination of alkynes: efficient synthesis of 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.

Organic letters (2012-10-24)
Tao Xu, Guosheng Liu
PMID23088282
RESUMO

A silver-catalyzed intramolecular oxidative aminofluorination of alkynes has been developed by using NFSI as a fluorinating reagent. This reaction represents an efficient method for the synthesis of various 4-fluoroisoquinolines and 4-fluoropyrrolo[α]isoquinolines.

MATERIAIS
Número do produto
Marca
Descrição do produto
209139
Sigma-Aldrich
Nitrato de prata, ACS reagent, ≥99.0%
S6506
Sigma-Aldrich
Nitrato de prata, ReagentPlus®, ≥99.0% (titration)
31630
Sigma-Aldrich
Nitrato de prata, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8%
204390
Sigma-Aldrich
Nitrato de prata, 99.9999% trace metals basis
10220
Sigma-Aldrich
Nitrato de prata, meets analytical specification of Ph. Eur., BP, USP, 99.8-100.5%
248762
Sigma-Aldrich
Silver nitrate on silica gel, extent of labeling: ~10 wt. % loading, +230 mesh
85193
Sigma-Aldrich
Nitrato de prata, 2.5 % (w/v) AgNO3 in H2O
85228
Sigma-Aldrich
Nitrato de prata, puriss. p.a., ≥99.5% (AT)
S7276
Sigma-Aldrich
Nitrato de prata, BioReagent, suitable for plant cell culture, >99% (titration)
S8157
Sigma-Aldrich
Nitrato de prata, BioXtra, >99% (titration)
85229
Sigma-Aldrich
Nitrato de prata, tested according to Ph. Eur.