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1082300

USP

Butoconazole nitrate

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

(±)-1-[4-(4-Chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole mononitrate

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About This Item

Fórmula empírica (Notação de Hill):
C19H17Cl3N2S · HNO3
Número CAS:
64872-77-1
Peso molecular:
474.79
Número MDL:
MFCD00058159
Código UNSPSC:
41116107
ID de substância PubChem:
329749174
NACRES:
NA.24
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grau

pharmaceutical primary standard

família API

butoconazole

fabricante/nome comercial

USP

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

cadeia de caracteres SMILES

ClC1=C(C(Cl)=CC=C1)SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3.O[N+]([O-])=O

InChI

1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)

chave InChI

ZHPWRQIPPNZNML-UHFFFAOYSA-N

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Descrição geral

Butoconazole nitrate (BN) is a imidazole used as an antifungal agent.[1]

Aplicação

Butoconazole nitrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monograph such as Butoconazole Nitrate Vaginal Cream.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P301 + P312 + P330

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Meng-meng Jia et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 34(3), 431-436 (2014-06-19)
A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of butoconazole in human plasma. Human plasma samples of 0.2 μL were pretreated by a single step protein precipitation procedure and analyzed using a high performance
J B Jacobson et al.
Acta obstetricia et gynecologica Scandinavica, 64(3), 241-244 (1985-01-01)
The continuously increasing incidence of vulvovaginal candidiasis necessitated a search for novel therapeutic modalities. Butoconazole nitrate (BN) a new imidazole, has been singled out for clinical studies since, in experimental vaginal candidiasis, it proved more effective than either miconazole nitrate
[Butoconazole nitrate in vulvovaginal candidiasis. A comparative study with clotrimazole].
E Herrera Nava et al.
Ginecologia y obstetricia de Mexico, 56, 138-143 (1988-05-01)
A J Hajman
The Journal of international medical research, 16(5), 367-375 (1988-09-01)
Sixty-three women with laboratory confirmed diagnoses of vulvovaginal candidosis were enrolled into this randomized, single-blind, parallel comparison of treatment with 2% butoconazole nitrate cream for 3 days and 1% clotrimazole cream for 6 days. Approximately 1 week after treatment ended
P Bourée et al.
Pathologie-biologie, 40(5), 492-494 (1992-05-01)
An in vitro study was carried out on ten first clinical isolates of Trichomonas vaginalis. Increasing levels of butaconazole were added to 150 microliters of a dilution in Roiron medium adjusted to 50,000 Trichomonas/ml. Results were read after 1, 2
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