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Documentos Principais

1000420

USP

Abacavir Related Compound A

United States Pharmacopeia (USP) Reference Standard

Sinônimo(s):

(1S,4R)-4-[2,6-Diamino-9H-purin-9-yl]-2-cyclopentene-1-methanol

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About This Item

Fórmula empírica (Notação de Hill):
C11H14N6O
Número CAS:
124752-25-6
Peso molecular:
246.27
Número MDL:
MFCD00869644
Código UNSPSC:
41116107
NACRES:
NA.24
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grau

pharmaceutical primary standard

família API

abacavir

fabricante/nome comercial

USP

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[n]2(c3nc(nc(c3nc2)N)N)[C@@H]1C[C@@H](C=C1)CO

InChI

1S/C11H14N6O/c12-9-8-10(16-11(13)15-9)17(5-14-8)7-2-1-6(3-7)4-18/h1-2,5-7,18H,3-4H2,(H4,12,13,15,16)/t6-,7+/m1/s1

chave InChI

ZKJUXHDSLJYKED-RQJHMYQMSA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Abacavir Related Compound A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Nota de análise

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Outras notas

Sales restrictions may apply.

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Pictogramas

Corrosion
GHS05

Palavra indicadora

Danger

Frases de perigo

H318

Declarações de precaução

P280 - P305 + P351 + P338

Classificações de perigo

Eye Dam. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

Lamentamos, não temos COA para este produto disponíveis online no momento.

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Evaluation of gastrointestinal absorption and metabolism.
C L Zimmerman et al.
Drug metabolism reviews, 29(4), 957-975 (1998-01-09)
Y D Wen et al.
Pharmaceutical research, 12(6), 911-915 (1995-06-01)
Evaluate the ability of (-)-6-aminocarbovir ((-)-6AC) to improve the CNS exposure to (-)-carbovir ((-)-CBV). Activation of (-)-6AC in vitro was assessed by incubations of rat brain tissue homogenates. The in vivo brain exposure to (-)-CBV was then examined in rats
C L Zimmerman et al.
Drug metabolism and disposition: the biological fate of chemicals, 20(1), 47-51 (1992-01-01)
The recently synthesized carbocyclic 2',3'-didehydro-2',3'-dideoxy-6-deoxy-6-amino-guanosine [(-)6AC] was evaluated as a prodrug for carbovir, carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine [(-)CBV] in seven male Sprague-Dawley rats. A randomized three-way cross-over design was used. Rats were assigned to receive the following treatments: a 20 mg/kg (-)6AC
Lack of effect of catheterization on the pharmacokinetics of (-)-carbovir in rats.
C L Zimmerman et al.
Pharmaceutical research, 13(9), 1417-1418 (1996-09-01)
Y Wen et al.
Drug metabolism and disposition: the biological fate of chemicals, 27(1), 113-121 (1999-01-12)
Several in vitro and in situ approaches were used to determine the dominant presystemic activation site for (-)-6-aminocarbovir, (-)-carbocyclic 2',3'-didehydro-2', 3'-dideoxy-6-deoxy-6-aminoguanosine (6AC) conversion in rats. The in vitro disappearance half-lives (mean +/- S.D.) in the cytosolic fractions obtained from homogenates
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Small Molecule HPLC

Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).

HPLC de moléculas pequenas

Moléculas pequenas são íons e compostos de peso molecular geralmente inferior a 900 daltons. Esses compostos podem ser separados e analisados de forma eficaz por HPLC, UHPLC e LC-MS, usando principalmente partículas de sílica ou fases estacionárias monolíticas com colunas de diversas composições (modificações) químicas.

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