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WH0084254M1

Monoclonal Anti-CAMKK1 antibody produced in mouse

Name: Monoclonal Anti-CAMKK1 antibody produced in mouse
Brand: SIGMA

clone 1F6, purified immunoglobulin, buffered aqueous solution

Sinônimo(s):

Anti-CAMKKA, Anti-DKFZp761M0423, Anti-MGC34095, Anti-calcium/calmodulin-dependent protein kinase kinase 1, alpha

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About This Item

Código UNSPSC:

12352203

NACRES:

NA.41

fonte biológica

mouse

conjugado

unconjugated

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

1F6, monoclonal

forma

buffered aqueous solution

reatividade de espécies

human

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL

Isotipo

IgG1κ

nº de adesão GenBank

BC031647

nº de adesão UniProt

Q8N5S9

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CAMKK1(84254)

Descrição geral

Calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1) is a member of the serine/threonine-protein kinase family. The CAMKK1 gene is mapped to human chromosome 17p13.2. It is expressed in the brain, as well as in the thymus and spleen.

Imunogênio

CAMKK1 (AAH31647, 1 a.a. ~ 520 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSRLLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQNQAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKNEPVVFPEGPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNLLV

Ações bioquímicas/fisiológicas

Calcium/calmodulin-dependent protein kinase 1 (CAMKK1) participates in the calcium/calmodulin-dependent (CaM) kinase cascade. It phosphorylates CAMK1 at threonine 177. Functionally, the members of the CAMKKs family are involved in neurite development, long-term memory (LTM), and axon elongation.

forma física

Solution in phosphate buffered saline, pH 7.4

Informações legais

GenBank is a registered trademark of United States Department of Health and Human Services

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificados de análise (COA)

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Structural Analysis of Inhibitor Binding to CAMKK1 Identifies Features Necessary for Design of Specific Inhibitors.

André da Silva Santiago et al.

Scientific reports, 8(1), 14800-14800 (2018-10-06)

The calcium/calmodulin-dependent protein kinases (CAMKKs) are upstream activators of CAMK1 and CAMK4 signalling and have important functions in neural development, maintenance and signalling, as well as in other aspects of biology such as Ca2+ signalling in the cardiovascular system. To

Multiple myeloma primary cells show a highly rearranged unbalanced genome with amplifications and homozygous deletions irrespective of the presence of immunoglobulin-related chromosome translocations.

Cristina Largo et al.

Haematologica, 92(6), 795-802 (2007-06-07)

Multiple myeloma (MM) is a malignant plasma cell neoplasia in which genetic studies have shown that genomic changes may affect almost all chromosomes, as shown by fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH). Our objective was the

Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.

Kazutaka Nanba et al.

Endocrinology, 156(5), 1750-1756 (2015-02-14)

There is considerable evidence supporting the role of calcium signaling in adrenal regulation of both aldosterone synthase (CYP11B2) and aldosterone production. However, there have been no studies that investigated the role played by the Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) in

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