About This Item
Fórmula empírica (Notação de Hill):
C22H38N6O7
Número CAS:
Peso molecular:
498.57
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
Ensaio
≥97% (HPLC)
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
CC(C)C(N)C(=O)NCC(=O)NC(C(C)C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NCC(O)=O
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Ações bioquímicas/fisiológicas
Chemotactic toward fibroblasts and monocytes.
Recognition sequence for the elastin receptor. Acts on vascular smooth muscle cells to release matrix metalloproteinase 1 (collagenase) and may induce angiogenesis.
Outras notas
Repeating peptide in elastin.
Código de classe de armazenamento
13 - Non Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Certificados de análise (COA)
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Nicolas Floquet et al.
Biopolymers, 76(3), 266-280 (2004-05-19)
Elastic fibers are an important component of the extracellular matrix, providing elasticity and resilience to tissues that require the ability to deform repetitively and reversibly. Among the elastin-derived peptides, the Val-Gly-Val-Ala-Pro-Gly (VGVAPG) hexapeptide is known for its chemotactic activity and
G B Nackman et al.
Surgery, 122(1), 39-44 (1997-07-01)
Infusion of the abdominal aorta with pancreatic elastase induces aneurysms in a rat model (Anidjar/Dobrin). Because elastolysis liberates elastin degradation products (EDPs), the present experiment was carried out to test the hypothesis that an EDP alone could induce features of
C Lombard et al.
Biochimie, 88(12), 1915-1921 (2006-09-02)
In normal and pathological tissues, polymorphonuclear leukocyte proteases (elastase, cathepsin G and proteinase 3) may generate soluble peptides through limited proteolysis of elastin, the main component of mature elastic fibres. Elastin-derived peptides display diverse biological activities including cell migration, differentiation
J Condeelis et al.
Cancer metastasis reviews, 11(1), 55-68 (1992-03-01)
Amoeboid movement, and in some cases, amoeboid chemotaxis, is a key step in tumor metastasis. The high degree of conservation in signal transduction pathways and motile machinery in eukaryotic cells suggests that insights and molecular probes developed from the study
Kirk A Hance et al.
Journal of vascular surgery, 35(2), 254-261 (2002-02-21)
Chronic inflammation is a characteristic feature of abdominal aortic aneurysms (AAAs), but the molecular signals responsible for recruiting monocytes into the outer aortic wall are unresolved. The purpose of this study was to examine whether AAA tissues elaborate chemotactic activity
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