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T7783

Sigma-Aldrich

Thonzonium bromide

Sinônimo(s):

Hexadecyl(2-[(p-methoxybenzyl)-2-pyrimidinylamino]ethyl)dimethylammonium bromide

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About This Item

Fórmula linear:
C32H55N4OBr
Número CAS:
553-08-2
Peso molecular:
591.71
Número CE:
209-032-1
Número MDL:
MFCD00133855
Código UNSPSC:
12161900
ID de substância PubChem:
24900475

descrição

cationic

peso molecular

591.71 g/mol

aplicação(ões)

sample preparation

cadeia de caracteres SMILES

Br.CCCCCCCCCCCCCCCC[N](C)(C)CCN(Cc1ccc(OC)cc1)c2ncccn2

InChI

1S/C32H55N4O.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27-36(2,3)28-26-35(32-33-24-19-25-34-32)29-30-20-22-31(37-4)23-21-30;/h19-25H,5-18,26-29H2,1-4H3;1H

chave InChI

PBWQBSCBSFJTLE-UHFFFAOYSA-N

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Aplicação

Thonzonium bromide may be use to inhibit vacuolar ATPases (V-ATPases) to induce and study the effects of cytosolic acidification. Thonzonium bromide is also used to further characterize V-ATPases. Thonzonium bromide is use as a potential pDNA particle condenser.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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A multifunctional nano device as non-viral vector for gene delivery: in vitro characteristics and transfection.
Gao Y, Gu W, Chen L, Xu Z, Li Y.
J. Controlled Release, 118, 381-388 (2007)
Ryosuke Suzuki et al.
Biological & pharmaceutical bulletin, 31(6), 1237-1243 (2008-06-04)
Non-viral DNA vectors are promising gene delivery systems and a variety of non-viral DNA vectors have been developed to date. Recently, we developed a novel non-viral gene delivery system--multifunctional envelope-type nano device (MEND). The MEND system has high transfection activity
Rebecca M Johnson et al.
Analytical biochemistry, 398(2), 203-211 (2009-12-19)
Fluorescence intensity of the pH-sensitive carboxyfluorescein derivative 2,7-bis(2-carboxyethyl)-5(6)-carboxyfluorescein (BCECF) was monitored by high-throughput flow cytometry in living yeast cells. We measured fluorescence intensity of BCECF trapped in yeast vacuoles, acidic compartments equivalent to lysosomes where vacuolar proton-translocating ATPases (V-ATPases) are
Chun-Yuan Chan et al.
The Journal of biological chemistry, 287(13), 10236-10250 (2012-01-05)
Vacuolar ATPases (V-ATPases) are important for many cellular processes, as they regulate pH by pumping cytosolic protons into intracellular organelles. The cytoplasm is acidified when V-ATPase is inhibited; thus we conducted a high-throughput screen of a chemical library to search
Cristiana Lalli et al.
PLoS neglected tropical diseases, 9(1), e0003484-e0003484 (2015-01-31)
Schistosomiasis, one of the world's greatest neglected tropical diseases, is responsible for over 280,000 human deaths per annum. Praziquantel, developed in the 1970s, has high efficacy, excellent tolerability, few and transient side effects, simple administration procedures and competitive cost and

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