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T6638

Sigma-Aldrich

Tolnaftate

Sinônimo(s):

Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester

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About This Item

Fórmula empírica (Notação de Hill):
C19H17NOS
Número CAS:
2398-96-1
Peso molecular:
307.41
Número CE:
219-266-6
Número MDL:
MFCD00056611
Código UNSPSC:
51302004
ID de substância PubChem:
24900394
NACRES:
NA.85

Formulário

powder

condição de armazenamento

(Keep container tightly closed in a dry and well-ventilated place.)

cor

white to off-white

solubilidade

chloroform: soluble 50 mg/mL

espectro de atividade do antibiótico

fungi

Modo de ação

enzyme | inhibits

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3

InChI

1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3

chave InChI

FUSNMLFNXJSCDI-UHFFFAOYSA-N

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Aplicação

Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm[1]. It also has been used as a comparator compound for antifungal efficiency studies[2].

Ações bioquímicas/fisiológicas

Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms[1]. Tolnaftate inhibits biosynthesis of aflatoxin.

Embalagem

1G,5G

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
089M4807V
116M4783V
086M4750V
056M4792V
BCBK6699V

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A K Dash et al.
Journal of pharmaceutical sciences, 91(4), 983-990 (2002-04-12)
Ethylcellulose microspheres containing tolnaftate (I) were prepared by the emulsion-solvent evaporation technique. An X-ray powder diffractometric method was developed to quantify the content of crystalline I in these microspheres. X-ray lines of I with d-spacings of 5.5 and 4.2 A
Y Kobayashi et al.
Chemical & pharmaceutical bulletin, 46(11), 1797-1802 (1998-12-10)
The enhancing effects of various vehicles on the in vitro permeation of a hydrophilic model drug, 5-fluorouracil (5-FU), or a lipophilic model drug, tolnaftate (TN), through human nail plates were investigated using a modified side-by-side diffusion cell. Tip pieces from
Toma Kezutyte et al.
Acta poloniae pharmaceutica, 67(4), 327-334 (2010-07-20)
Abstract: Tolnaftate, an antifungal of thiocarbamate class, is used topically in 1% formulations. Its penetration into skin layers is a prerequisite for tolnaftate action against dermatophytes. The aim of this work was to optimize and validate a simple, rapid, accurate
T Ohmi et al.
Arzneimittel-Forschung, 41(8), 847-851 (1991-08-01)
In vitro and in vivo antifungal activities of the new imidazole derivative latoconazole ((+-)-(E)-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-1- imidazolylacetonitrile, NND-318; CAS 101530-10-3) were studied in comparison with three major topical agents, clotrimazole, bifonazole and tolnaftate. The in vitro activity of latoconazole against dermatophytes was
Toma Kezutyte et al.
Acta poloniae pharmaceutica, 68(6), 965-973 (2011-12-01)
Five fatty acids (oleic, linoleic, myristic, lauric and capric) were incorporated in 10% (w/w) into ointment formulation and their influence on lipophilic model drug tolnaftate release in vitro and enhancing effect on tolnaftate penetration into epidermis and dermis of human
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