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SRP8017

Sigma-Aldrich

Progranulin rat

recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE)

Sinônimo(s):

PEPI, Proepithelin

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About This Item

Número CAS:
139316-59-9
Código UNSPSC:
12352202
NACRES:
NA.32

fonte biológica

rat

recombinante

expressed in HEK 293 cells

etiqueta

FLAG® tagged

Ensaio

>95% (SDS-PAGE)

forma

lyophilized

peso molecular

~65 kDa by SDS-PAGE

embalagem

pkg of 10 μg

fabricante/nome comercial

Sigma-Aldrich

condição de armazenamento

avoid repeated freeze/thaw cycles

Impurezas

<0.1 EU/μg endotoxin, tested

cor

white

nº de adesão UniProt

P23785

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

rat ... Grn(29143)

Descrição geral

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

forma física

Lyophilized from 0.2 μm-filtered solution in PBS.

Reconstituição

Reconstitute with 100 μL deionized water.

Outras notas

Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag.

Informações legais

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
Masato Kanazawa et al.
Brain : a journal of neurology, 138(Pt 7), 1932-1948 (2015-04-04)
In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding protein-43-positive frontotemporal lobar degeneration. Although several studies have reported that progranulin plays a protective role
Michael J Smout et al.
PLoS pathogens, 11(10), e1005209-e1005209 (2015-10-21)
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury

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