SRP8009

GITRL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >90% (SDS-PAGE)

• Sinônimo(s): AITRL, EGF-like protein 9, Glucocorticoid-induced TNF receptor ligand, TNFSF18
• Código UNSPSC: 12352202
• NACRES: NA.32

Propriedades

• fonte biológica: mouse
• recombinante: expressed in HEK 293 cells
• etiqueta: FLAG^® tagged
• Ensaio: >90% (SDS-PAGE)
• Formulário: liquid
• peso molecular: ~22 kDa by SDS-PAGE
• embalagem: pkg of 50 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• concentração: ≥0.2 mg/mL
• Impurezas: <0.1 EU/μg endotoxin, tested
• cor: clear
• nº de adesão UniProt: Q7TS55
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: mouse ... Tnfsf18(240873)

Descrição

Descrição geral

GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

forma física

Solution in 10 mM glycine, pH 10.0.

Outras notas

The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG^®-tag.

Informações legais

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable