SRP6577

TAF1 (1371-1496) GST tag human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• Sinônimo(s): BA2R, CCG1, CCGS, DYT3, KAT4, NSCL2, TAF1 RNA Polymerase II, TAF2A, TAFII250, TATA Box Binding Protein (TBP)-Associated Factor, XDP
• Código UNSPSC: 12352200
• NACRES: NA.32

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥95% (SDS-PAGE)
• Formulário: liquid
• peso molecular: 41.7 kDa (1371-1496 aa + NT GST Tag)
• embalagem: pkg of 100 μg; pkg of 20 μg
• nº de adesão UniProt: P21675
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... TAF1(6872)

Descrição

Descrição geral

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TAF1 is a component of transcription factor IID, and binds to core promoter sequences at the transcription start site. TAF1 helps control transcription by both its kinase and histone acetyltransferase enzymatic activities. It interacts with transcriptional activators such as the androgen receptor to promote transcription. Disruption of TAF1 causes dystonia 3 (X-linked torsion dystonia) and decreased apoptosis. This protein product contains the first bromodomain of TAF1.

forma física

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H317,H319
• Declarações de precaução: P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Sens. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable