SRP6526

FTO human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Sinônimo(s): FATSO, Fat Mass and Obesity-associated Protein
• Código UNSPSC: 12352200
• NACRES: NA.32

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥90% (SDS-PAGE)
• forma: liquid
• peso molecular: ~65 kDa (Human FTO aa 2-505 is fused at the N-terminus to a His-tag.)
• embalagem: pkg of 10 μg
• concentração: 0.2 mg/mL
• Impurezas: <1 EU/μg endotoxin (LAL test)
• nº de adesão UniProt: Q9C0B1
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... FTO(79068)

Descrição

Descrição geral

FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.

The fat mass and obesity-associated (FTO) gene is mapped to human chromosome 16q12.2. The encoded protein is a nuclear protein and belongs to the AlkB-related non-haem iron- and 2-oxoglutarate-dependent dioxygenase family.

Ações bioquímicas/fisiológicas

FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower high-density lipoprotein (HDL)-cholesterol. FTO stimulates adipogenesis, tumorigenesis, and drug resistance of cancer cells. It does so by reducing the levels of messenger RNA N6-methyladenosine (m6A) of certain genes post-transcription. The FTO single-nucleotide polymorphisms (SNPs) are associated with elevated body mass and obesity in humans.

forma física

0.2 mg/mL of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl.

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable