SRP6508

Haptoglobin (Phenotype 2-2) from human plasma

≥95% (SDS-PAGE)

• Sinônimo(s): Hp 2-2
• Código UNSPSC: 12352202
• NACRES: NA.32

Propriedades

• fonte biológica: human plasma
• Ensaio: ≥95% (SDS-PAGE)
• Formulário: lyophilized
• peso molecular: 170-900 kDa
• embalagem: pkg of 1 mg
• nº de adesão UniProt: P00738
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... HP(3240)

Descrição

Descrição geral

Haptoglobin(Hp) is an acute-phase antioxidant,[1] found abundantly in the plasma[2] , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2.[1] The HP gene is mapped on the human chromosome at16q22.2.[3]

Aplicação

Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells.[4] It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.[5]

Ações bioquímicas/fisiológicas

Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage.[2] Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1.[6][7] Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy.[8] It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes.[2] Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.[8]

forma física

Lyophilized as a salt-free solid.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable