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SRP5373

Sigma-Aldrich

INCENP, His tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinônimo(s):

FLJ31633, MGC111393

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

recombinante

expressed in baculovirus infected Sf9 cells

Ensaio

≥70% (SDS-PAGE)

forma

buffered aqueous glycerol solution

peso molecular

~19 kDa

nº de adesão NCBI

NM_001040694

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... INCENP(3619)

Descrição geral

INCENP or inner centromere protein antigens 135/155kDa is a constitutively binding centromere proteins and ′passenger,′ or transiently interacting, proteins. The overexpression of a truncation mutant of chicken INCENP and a chimeric CENPB:INCENP protein in mammalian cell culture disrupted both prometaphase chromosome alignment and completion of cytokinesis. INCENP forms a complex with the evolutionarily conserved family of Aurora B kinases which helps coordinate chromosome segregation, spindle behavior, and cytokinesis during mitosis.

Ações bioquímicas/fisiológicas

As part of the chromosomal passenger complex (CPC), inner centromere protein (INCENP) has a role in assembly and stability of the complex. It also aids in the centromere localization of CPC. INCENP has a role in mitosis and associates with microtubules. The protein has been shown to be upregulated in colorectal cancer cell lines.

forma física

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

Nota de preparo

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Danger

Frases de perigo

H315,H319,H360D

Classificações de perigo

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Inherited variants in the inner centromere protein (INCENP) gene of the chromosomal passenger complex contribute to the susceptibility of ER-negative breast cancer.
Kabisch M, et.al
Carcinogenesis, 36(2), 256-271 (2015)
INCENP binds directly to tubulin and requires dynamic microtubules to target to the cleavage furrow.
Wheatley SP, et.al
Experimental Cell Research, 262(2), 122-127 (2001)
Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells.
Adams RR, et.al
Chromosoma, 110(2), 65-74 (2001)
R R Adams et al.
Chromosoma, 110(2), 65-74 (2001-07-17)
The inner centromere protein (INCENP), which has previously been described in chicken, frog and mouse, is required for correct chromosome segregation and cytokinesis. We have identified the human INCENP gene by library screening and reverse transcription-polymerase chain reaction (RT-PCR) and
S P Wheatley et al.
Experimental cell research, 262(2), 122-127 (2001-01-05)
Inner centromere protein (INCENP) is a chromosomal passenger protein with an essential role in mitosis. At the metaphase/anaphase transition, some INCENP transfers from the centromeres to the central spindle; the remainder then transfers to the equatorial cortex prior to cleavage
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