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SRP5098

Sigma-Aldrich

ULK3, active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinônimo(s):

DKFZP434C131

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.32

recombinante

expressed in baculovirus infected Sf9 cells

linha de produto

PRECISIO® Kinase

Ensaio

≥70% (SDS-PAGE)

forma

buffered aqueous glycerol solution

atividade específica

195-265 nmol/min·mg

peso molecular

~51 kDa

nº de adesão NCBI

BC157884

Condições de expedição

dry ice

temperatura de armazenamento

−70°C

Informações sobre genes

human ... ULK3(25989)

Descrição geral

The ULK3 (unc-51 like kinase 3) gene is mapped to human chromosome 15q24.1.

Ações bioquímicas/fisiológicas

ULK3 or unc-51-like kinase 3 is a member of the serine/threonine kinase family that is involved in the SHH signaling pathway as a positive regulator of GLI proteins. ULK3 enhances endogenous and over-expressed GLI transcriptional activity in cultured cells and alters its subcellular localization. Furthermore, ULK3 phosphorylates GLI proteins in vitro. ULK3 is widely expressed and its expression is higher in a number of tissues where SHH signaling is known to be active, again suggesting that ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins. ULK3 participates in cell cycle checkpoint and prevents the progression of cell division prior to complete chromosome separation. Overexpression of ULK3 stimulates autophagy through fibroblast activation.

forma física

Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Nota de preparo

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Informações legais

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Danger

Frases de perigo

H315,H319,H360D

Classificações de perigo

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 1

Certificados de análise (COA)

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ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins
Caballe A, et al.
eLife, 4(10), e06547-e06547 (2015)
Novel genes affecting blood pressure detected via gene-based association analysis
Zhang H,et al.
Genes & Genomics, g3-115 (2015)
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI
Goruppi , et al.
Testing, 20(10), 2468-2479 (2017)
Alla Maloverjan et al.
Experimental cell research, 316(4), 627-637 (2009-11-03)
The Hedgehog (Hh) signaling pathway plays crucial roles in embryonic development and is implicated in tissue homeostasis maintenance and neurogenesis in adults. Aberrant activation of Hh signaling is associated with various developmental abnormalities and several types of cancer. Genetic and

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