SRP2163

Estrogen Receptor human

recombinant, expressed in insect cells, ≥80% (SDS-PAGE)

• Sinônimo(s): DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1
• Código UNSPSC: 12352200
• NACRES: NA.26

Propriedades

• fonte biológica: human
• recombinante: expressed in insect cells
• Ensaio: ≥80% (SDS-PAGE)
• Formulário: frozen liquid
• peso molecular: ~68 kDa
• embalagem: pkg of 4 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• concentração: 200 μg/mL
• cor: colorless to clear
• nº de adesão NCBI: NM_000125
• nº de adesão UniProt: P03372
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... ESR1(2099)

Descrição

Descrição geral

The gene ESR1 (estrogen receptor-alpha) encodes a member of the superfamily of nuclear hormone receptors that are essential for the functioning of female reproductive system. The gene is mapped to human chromosome 6q25.[1]

Ações bioquímicas/fisiológicas

Several members of the nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor alpha (RAR alpha) in acute promyelocytic leukemia. Estrogen receptors (ER) are members of the superfamily of nuclear hormone receptors (2, 3) whose activity is required for the normal function of the female reproductive system. Two isoforms of estrogen receptor (ER α and ER β) have been described. They function as ligand-dependent transcriptional activators. The biological functions downstream of ER result from altered expression of direct transcriptional targets as well as secondary effects mediated by biological activities of direct targets. In the mammary gland, estrogen receptors regulate normal epithelial cell development and differentiation through their well-documented effects on transcription. Estrogens have long been known to have mitogenic functions in breast cancer cell lines and in breast tumors. Selective estrogen receptor modulatory compounds (SERMs), which bind directly to ER, can block the growth stimulatory function of estrogens.

forma física

Clear and colorless frozen liquid solution

Nota de preparo

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable