SRP2143

RARγ, ligand binding domain (150-417), GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• Sinônimo(s): NR1B3, RARC
• Código UNSPSC: 12352202
• NACRES: NA.26

Propriedades

• fonte biológica: human
• recombinante: expressed in E. coli
• Ensaio: ≥70% (SDS-PAGE)
• forma: frozen liquid
• peso molecular: ~56 kDa
• embalagem: pkg of 10 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• concentração: 250 μg/mL
• cor: clear colorless
• nº de adesão NCBI: NM_000966
• nº de adesão UniProt: P13631
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... RARG(5916)

Descrição

Ações bioquímicas/fisiológicas

Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consist of three isotypes (α, β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, so-called retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. The RAR-gamma in the adult is found almost exclusively in the skin. Retinoids affect epidermal cell growth and differentiation as well as sebaceous gland activity and exhibit immunomodulatory and anti-inflammatory properties. Current retinoid research targets the development of receptor-selective retinoids for tailoring and/or improving their therapeutic profile.

forma física

Clear and colorless frozen liquid solution

Nota de preparo

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable